Anti-HCA57 (Polyclonal), ALEXA Fluor 594

Anti-HCA57 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Price 489

Size 100 microliters

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Type	Conjugated Primary Antibody
Conjugated with	594, ALEXA FLUOR®
Host organism	Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide	HCA57
Specificity	This antibody reacts specifically with HCA57
Modification	No modification has been applied to this antibody
Modification site	None
Clonality	Polyclonal Antibody
Clone	Polyclonal Antibodies
Concentration	1ug per 1ul
Subcellular locations	N/A
Antigen Source	KLH conjugated synthetic peptide derived from human TID1/HCA57
Gene ID	9093
Swiss Prot	N/A
Applications	IF(IHC-P)
Applications with corresponding dilutions	IF(IHC-P)(1:50-200)
Cross reactive species	Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details	However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information	A J domain mutant of hTid1L can dominantly suppress apoptosis and in sharp contrast the J domain mutant of hTid1S increases apoptosis, Expression of hTid1L increases apoptosis induced by DNA damaging agents as mitomycin C and TNF alpha, Expression of hTid1S and hTid1L affects cytochrome c release from the mitochondria and caspase 3 activation, Hence the relative abundance of these proteins or their substrates may allow the mitochondria to dampen or enhance the apoptotic signals, It is strongly suggested that these two splice variants exert their anti and pro apoptotic effects through discrete substrates and activities, These proteins are the conserved members of the DnaJ family of proteins which act as cochaperons for mitochondrial Hsp70, They contain a conserved tetrahedrical J domain which binds to Hsp70 chaperones and activates their ATPase activity, while activation of caspase 8 is unaffected, TID1 is a human homolog of the Drosophila tumor suppressor lethal tumerous imaginal discs and encodes two mitochondrial matrix localized splice variants of human Tid1 designated hTid1S and hTid1L
Purification method	Purified by Protein A
Storage	50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission	590nm/617nm
Synonyms	DNJA3_HUMAN, DnaJ homolog subfamily A member 3 mitochondrial precursor, DnaJ protein Tid 1, DnaJ protein Tid1, HCA57, Hepatocellular carcinoma associated antigen 57, Highly similar to HYPOTHETICAL 105, III [Caenorhabditis elegans], TID1, Tumorous imaginal discs Drosophila homolog, Tumorous imaginal discs protein Tid56 homolog, hTid 1, hTid1, 5 IN CHROMOSOME, 9 KD PROTEIN F22B7, DnaJ Hsp40 homolog subfamily A member 3
Also known as	HCA57 Polyclonal Antibody
Other name	Anti-HCA57 Polyclonal
Advisory	For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
Properties	For facs or microscopy Alexa 1 conjugate
Conjugation	Alexa Fluor
Group	Polyclonals and antibodies
About	The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene target	HCA57
Short name	Anti-HCA57 (Polyclonal) Fluor 594
Technique	Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different
Label	ALEXA
Alternative name	ALEXA Fluor 594, antibody to-HCA57 (polyclonal)
Alternative technique	polyclonals

Anti-HCA57 (Polyclonal), ALEXA Fluor 594

Anti-HCA57 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

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