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Anti-HCF2 (Polyclonal), ALEXA Fluor 594

Anti-HCF2 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideHCF2
SpecificityThis antibody reacts specifically with HCF2
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human HCF2/Heparin Cofactor II
Gene ID3053
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Also inhibits chymotrypsin, Defects in SERPIND1 are the cause of Heparin Cofactor II deficiency, Heparin Cofactor II becomes the predominant thrombin inhibitor in place of antithrombin III (AT III), Heparin Cofactor II deficiency is an important risk factor for hereditary thrombophilia, Heparin Cofactor II deficiency is inherited as an autosomal dominant disorder, Heparin Cofactor II is antigenically distinct from AT III, Heparin Cofactor II is normal in patients with AT III deficiency and is low in patients with disseminated intravascular coagulation, In the presence of the latter, It is expressed predominantly in liver, Its function is: thrombin inhibitor activated by the glycosaminoglycans, The N terminal acidic repeat region mediates, The first of these to be well characterized was antithrombin III, a multifactorial trait characterized by recurrent thrombosis and abnormal platelet aggregation in response to various agents, a viral transcription factor that activates the viral immediate-early (IE) genes, but in a glycosaminoglycan independent manner and peptides at the N terminal of Heparin Cofactor II have chemotactic activity for both monocytes and neutrophils, heparin or dermatan sulfate, in part, in which affected individuals are prone to develop serious spontaneous thrombosis, the glycosaminoglycan accelerated thrombin inhibition, The anticoagulant action of heparin is dependent on plasma components termed heparin cofactors, The herpes simplex virus (HSV) infection is initiated by VP16
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms HC-II HLS2 HC2 D22S673
Also known asHCF2 Polyclonal Antibody
Other nameAnti-HCF2 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetHCF2
Short nameAnti-HCF2 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-HCF2 (polyclonal)
Alternative techniquepolyclonals
Identity 4838
Gene SERPIND1
Long gene name serpin family D member 1
Synonyms gene HCF2
Synonyms gene name clade D (heparin cofactor), clade D (heparin cofactor), member 1 , member 1 serpin peptidase inhibitor, serine (or cysteine) proteinase inhibitor
Synonyms name heparin cofactor II heparin cofactor 2
Locus 22q11, 21
Discovery year 1988-05-31
GenBank acession M12849
Entrez gene record 3053
Pubmed identfication 1671335 24172014
RefSeq identity NM_000185
Classification Serpin peptidase inhibitors
Havana BLAST/BLAT OTTHUMG00000150755
Locus Specific Databases LRG_594

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