Name : Anti-HDAC8 (Polyclonal), ALEXA Fluor 594
Supplier : BIOSS POLYCLONAL ANTIBODIES
Price :489
SKU : GEN3026044067
| Type | Conjugated Primary Antibody |
| Conjugated with | 594, ALEXA FLUOR® |
| Host organism | Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide | HDAC8 |
| Specificity | This antibody reacts specifically with HDAC8 |
| Modification | No modification has been applied to this antibody |
| Modification site | None |
| Clonality | Polyclonal Antibody |
| Clone | Polyclonal Antibodies |
| Concentration | 1ug per 1ul |
| Subcellular locations | Nucleus, Cytoplasm |
| Antigen Source | KLH conjugated synthetic peptide derived from human HDAC8 |
| Gene ID | 55869 |
| Swiss Prot | Q9BY41 |
| Applications | IF(IHC-P) |
| Applications with corresponding dilutions | IF(IHC-P)(1:50-200) |
| Cross reactive species | Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details | However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information | Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin, H2B, H3 and H4), Histone deacetylases act via the formation of large multiprotein complexes, Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, May play a role in smooth muscle cell contractility, cell cycle progression and developmental events, Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A |
| Purification method | Purified by Protein A |
| Storage | 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission | 590nm/617nm |
| Synonyms | RPD3 |
| Also known as | HDAC8 Polyclonal Antibody |
| Other name | Anti-HDAC8 Polyclonal |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties | For facs or microscopy Alexa 1 conjugate |
| Conjugation | Alexa Fluor |
| Group | Polyclonals and antibodies |
| About | The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target | HDAC8 |
| Short name | Anti-HDAC8 (Polyclonal) Fluor 594 |
| Technique | Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different  |
| Label | ALEXA |
| Alternative name | ALEXA Fluor 594, antibody to-HDAC8 (polyclonal) |
| Alternative technique | polyclonals |
| Identity | 13315 |
| Gene | HDAC8 |
| Long gene name | histone deacetylase 8 |
| Synonyms gene | HDACL1 WTS MRXS6 |
| Synonyms gene name | histone deacetylase-like 1 Wilson-Turner X-linked mental retardation syndrome |
| Locus | Xq13, 1 |
| Discovery year | 2000-11-28 |
| GenBank acession | AF230097 |
| Entrez gene record | 55869 |
| Pubmed identfication | 10756090 10922473 22889856 |
| RefSeq identity | NM_018486 |
| Classification | X-linked mental retardation Histone deacetylases, class I |
| Havana BLAST/BLAT | OTTHUMG00000021814 |
| Locus Specific Databases | Mental Retardation database |