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Anti-HIC1 (Polyclonal), ALEXA Fluor 594

Anti-HIC1 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideHIC1
SpecificityThis antibody reacts specifically with HIC1
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human HIC1
Gene ID3090
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Conversely, HIC-1 does not interact with components of the HDAC complex, HIC-1 is deleted in the genetic disorder Miller-Dieker syndrome (MDS), HIC-1 is ubiquitously expressed in adult tissues and its structure is defined by five zinc fingers and an N-terminal broad complex POZ (or BTB) domain, In several BTB/POZ containing proteins, These and other studies indicate that HIC-1 acts as a putative tumor suppressor protein that mediates transcriptional repression, When this domain is deleted, and the expression of HIC-1 is also frequently suppressed in leukemia and various cancers due to the hypermethylation of specific DNA regions and the resulting transcriptional silencing, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, suggesting that HIC-1-induced transcriptional repression is unassociated with the POZ/BTB domain, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription, this transcriptional repression is attenuated, Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms ZBTB29 ZNF901
Also known asHIC1 Polyclonal Antibody
Other nameAnti-HIC1 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetHIC1
Short nameAnti-HIC1 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-HIC1 (polyclonal)
Alternative techniquepolyclonals
Identity 4909
Gene HIC1
Long gene name HIC ZBTB transcriptional repressor 1
Synonyms gene name hypermethylated in cancer 1
Locus 17p13, 3
Discovery year 1996-03-19
Entrez gene record 3090
RefSeq identity NM_006497
Classification BTB domain containing Zinc fingers C2H2-type
Havana BLAST/BLAT OTTHUMG00000177635

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