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Anti-HNF3 alpha (Polyclonal), ALEXA Fluor 594

Anti-HNF3 alpha (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideHNF3 alpha
SpecificityThis antibody reacts specifically with HNF3 alpha
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsNucleus
Antigen SourceKLH conjugated synthetic peptide derived from human FOXA1
Gene ID3169
Swiss ProtP55317
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity), FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity), Interacts with the cis-acting regulatory regions of these genes, Involved in cell cycle regulation by activating expression of CDKN1B, Involved in glucose homeostasis, Involved in regulation of apoptosis by inhibiting the expression of BCL2, Involved in the development of multiple endoderm-derived organ systems such as liver, Is involved in ESR1-mediated transcription, Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites, Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes, Modulates the transcriptional activity of nuclear hormone receptors, Originally described as a transcription activator for a number of liver genes such as AFP, PEPCK, Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs, albumin, alone or in conjunction with BRCA1, binds to the RPRM promter and is required for the estrogen-induced repression of RPRM, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues, etc, lung and prostate, pancreas, required for ESR1 binding to the NKX2-1 promoter in breast cancer cells, tyrosine aminotransferase, Transcription factor that is involved in embryonic development
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms FOXA1, Forkhead box protein A1, HNF-3-alpha, HNF-3A, Hepatocyte nuclear factor 3-alpha, TCF-3A, TCF3A, Transcription factor 3A, HNF3A
Also known asHNF3 alpha Polyclonal Antibody
Other nameAnti-HNF3 alpha Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetHNF3 alpha
Short nameAnti-HNF3 alpha (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-HNF3 a (polyclonal)
Alternative techniquepolyclonals

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