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Anti-HUMAN CD254:Biotin Antibody

Anti-HUMAN CD254:Biotin Antibody size: 50ug 636

Supplier MBS POLYCLONALS 1
Price 636
Size 50ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Alternative name1Anti-RABBIT ANTI HUMAN CD254:Biotin
Alternative name2RABBIT ANTI HUMAN CD254:Biotin
Alternative name3Lapin ANTI Homo sapiens CD254:Biotin
Alternative name4CD254
Alternative name5N/A
Other names ODF, OPGL, Osteoclast differentiation factor, Osteoprotegerin ligand, RANKL, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, TNF-related activation-induced cytokine, Tumor necrosis factor ligand superfamily member 11, member 11, osteoclast differentiation factor, osteoprotegerin ligand, receptor activator of nuclear factor kappa B ligand, receptor activator of nuclear factor kappa-B ligand, tumor necrosis factor (ligand) superfamily, tumor necrosis factor ligand superfamily member 11, tumor necrosis factor ligand superfamily member 11 isoform 1
Gene nameCD254
Gene name synonimsN/A
Other gene names CD254, ODF, ODF, OPGL, OPGL, OPGL, OPTB2, RANKL, RANKL, RANKL, TNFSF11, TRANCE, TRANCE, TRANCE, hRANKL2, sOdf, TNFSF11
CategoryAntibodies
ClonalityPolyclonal
Immunoglobulin isotypePolyclonal IgG
ClonePolyclonal antibody
Host organismRabbit
Species reactivityHuman
Specificity and cross-reactivity Binding of CD254 to RANK is essential for the activation of osteoclastogenesis, IL-1beta, IL-6 and IL-17, Studies have also revealed a link between CD254 and apoptosis, _x000D__x000D_CD254 is highly expressed by T lymphocytes and osteoblastic cells and plays a key role in the differentiation and activation of osteoclast precursors, _x000D__x000D_Studies have shown that CD254 augments the dendritic cell (DC) stimulation of naï, a 20kDa glycoprotein and member of the Tumour Necrosis Factor (TNF) superfamily, acting as a ligand for both receptor activator of NF-KBeta (RANK) and the decoy receptor osteoprotegerin (OPG), generated by proteolytic processing of the full-length CD254 membrane protein, otherwise known as sRANKL, stimulated by factors such as TNF-alpha, thereby inhibiting osteoclastogenesis, through activation of the antiapoptotic kinase AKT/PKB and the mTOR/S6K signalling pathway, whereas binding to OPG neutralizes CD254, which act as antagonists, CD254 This item is specific for the soluble form of human CD254, ve T cell proliferation and may be involved in the regulation of DC-T cell interactions
Purification methodN/A
Form/AppearanceBiotin (Purified IgG conjugated to Biotin - lyophilised)
ConcentrationIgG concentration 50ug/ml
Storage and shipping After reconstitution For optimal long term storage, Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 12 months from date of reconstitution, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, productone should be kept at -20 degrees Celsius, productone should be stored undiluted, Prior to reconstitution store at +Store productone at +4 degrees Celsius
Tested for: ELISA (EIA), Western Blot (WB)
Description Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24°
ConjugationBiotinylated
Gene targetCD254:
Short nameAnti-HUMAN CD254: Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelBiotin
Alternative name sapiens CD254:biotinilated (Antibody to), antibody to-H
Alternative techniqueantibodies
Identity 11926
Gene TNFSF11
Long gene name tumor necrosis factor superfamily member 11
Synonyms gene name member 11 , tumor necrosis factor (ligand) superfamily
Synonyms TRANCE RANKL OPGL ODF CD254
Locus 13q14
Discovery year 1998-12-04
GenBank acession AF013171
Pubmed identfication 9312132 9367155
Classification Tumor necrosis factor superfamily CD molecules
Havana BLAST/BLAT OTTHUMG00000016807

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