Anti-IKAP (Polyclonal), ALEXA Fluor 594

Anti-IKAP (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Price 489

Size 100 microliters

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Type	Conjugated Primary Antibody
Conjugated with	594, ALEXA FLUOR®
Host organism	Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide	IKAP
Specificity	This antibody reacts specifically with IKAP
Modification	No modification has been applied to this antibody
Modification site	None
Clonality	Polyclonal Antibody
Clone	Polyclonal Antibodies
Concentration	1ug per 1ul
Subcellular locations	N/A
Antigen Source	KLH conjugated synthetic peptide derived from human IKAP
Gene ID	N/A
Swiss Prot	N/A
Applications	IF(IHC-P)
Applications with corresponding dilutions	IF(IHC-P)(1:50-200)
Cross reactive species	Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details	However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information	Activation of NFkB requires that IkB be phosphorylated on specific serine residues, IKAP (IKK-complex-associated protein) is a protein that acts as a scaffold, IKK alpha, IKK alpha and IKK beta and assembling them into an active kinase complex (7, IKK beta and IKK gamma (also designated NEMO), IKKalpha appears to be critical for NFkB activation in response to proinflammatory cytokines (4), IkB kinase alpha (IKK alpha), Phosphorylation of the IkB by IKK alpha is stimulated by the NFkB inducing kinase (NIK), The functional IKK complex contains three subunits, and each appears to make essential contributions to IkB phosphorylation (6), interacting with NIK, interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation, previously designated CHUK (2), serines 32 and 36 (3), which itself is a central regulator for NFkB activation in response to TNF and IL-1 (5), which results in the targeted degradation of IkB (1), 8), The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB
Purification method	Purified by Protein A
Storage	50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission	590nm/617nm
Synonyms	IKAP TOT1 ELP1 IKI3
Also known as	IKAP Polyclonal Antibody
Other name	Anti-IKAP Polyclonal
Advisory	For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
Properties	For facs or microscopy Alexa 1 conjugate
Conjugation	Alexa Fluor
Group	Polyclonals and antibodies
About	The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene target	IKAP
Short name	Anti-IKAP (Polyclonal) Fluor 594
Technique	Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different
Label	ALEXA
Alternative name	ALEXA Fluor 594, antibody to-IKAP (polyclonal)
Alternative technique	polyclonals
Identity	5959
Gene	IKBKAP
Long gene name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
Synonyms gene	DYS
Synonyms gene name	dysautonomia (Riley-Day syndrome, hereditary sensory autonomic neuropathy type III)
Synonyms name	elongator acetyltransferase complex subunit 1
Locus	9q31, 3
Discovery year	1998-09-30
GenBank acession	AF044195
Entrez gene record	8518
Pubmed identfication	9751059 11179008
Classification	Elongator acetyltransferase complex
Havana BLAST/BLAT	OTTHUMG00000020465
Locus Specific Databases	Inherited Peripheral Neuropathies Mutation Database LRG_251

Anti-IKAP (Polyclonal), ALEXA Fluor 594

Anti-IKAP (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

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