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Anti-IKK beta(Tyr199) (Polyclonal), ALEXA Fluor 594

Anti-IKK beta(Tyr199) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 516
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideIKK beta Tyr199
SpecificityIKK beta(Tyr199), This phosphorylation site is homologous across the listed species
ModificationPhosphorylation
Modification siteTyr199
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locations Nucleus, Cytoplasm
Antigen SourceKLH conjugated synthetic phosphopeptide derived from human IKK beta around the phosphorylation site of Tyr199
Gene ID3551
Swiss ProtO14920
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues, Also phosphorylates other substrates including NCOA3, BCL10 and IRS1, DNA damages or other cellular stresses, IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs, In addition to the NF-kappa-B inhibitors, In turn, NF-kappa-B subunits RELA and NFKB1, These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome, Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation, as well as IKK-related kinases TBK1 and IKBKE, bacterial or viral products, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-B, IKK-beta, IKKB, IMD15, IkBKB, Inhibitor of nuclear factor kappa-B kinase subunit beta, NFKBIKB, Nuclear factor NF-kappa-B inhibitor kinase beta, IKK2
Also known asIKK beta(Tyr199) Polyclonal Antibody
Other nameAnti-IKK beta(Tyr199) Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetIKK beta(Tyr199)
Short nameAnti-IKK beta(Tyr199) (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-IKK b(Tyr199) (polyclonal)
Alternative techniquepolyclonals

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