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Anti-JIP2 (Polyclonal), ALEXA Fluor 594

Anti-JIP2 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideJIP2
SpecificityThis antibody reacts specifically with JIP2
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human JIP2
Gene IDN/A
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding (6), Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, Multiple splice variants if JIP-1, Ser-63 and Ser-73, Two additional JNK family members have been identified as JNK2 and JNK3 (3), and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites, have been identified in brain (7), including JIP-1b, resulting in transcriptional activation (2-5), thereby inhibiting JNK-regulated gene expression, which are targets of the JNK signaling pathway, c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family (1)
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms IB2 JIP2
Also known asJIP2 Polyclonal Antibody
Other nameAnti-JIP2 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetJIP2
Short nameAnti-JIP2 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-JIP2 (polyclonal)
Alternative techniquepolyclonals
Identity 6883
Gene MAPK8IP2
Long gene name mitogen-activated protein kinase 8 interacting protein 2
Synonyms gene PRKM8IPL
Synonyms gene name PRKM8 interacting protein-like
Synonyms name islet-brain 2 JNK-interacting protein 2
Locus 22q13, 33
Discovery year 1999-10-12
GenBank acession AL021708
Entrez gene record 23542
Pubmed identfication 10490659
RefSeq identity NM_012324
Havana BLAST/BLAT OTTHUMG00000150181

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