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Anti-KDM1A (Polyclonal), ALEXA Fluor 594

Anti-KDM1A (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideKDM1A
SpecificityThis antibody reacts specifically with KDM1A
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsNucleus
Antigen SourceKLH conjugated synthetic peptide derived from human KDM1A
Gene ID23028
Swiss ProtO60341
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Acts as a corepressor by mediating demethylation of H3K4me, Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed, Alone, Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, CDN7 and KRT8, Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, Demethylates and stabilizes the DNA methylase DNMT1, Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me, Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation, Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, May play a role in the repression of neuronal genes, Required for gastrulation during embryogenesis, Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7, The presence of PRKCB in ANDR-containing complexes, a number of genes implicated in multilineage blood cell development, a specific tag for epigenetic transcriptional activation, a specific tag for epigenetic transcriptional repression, a specific tag that prevents demethylation H3K4me, by being recruited to ANDR target genes and mediating demethylation of H3K9me, depending on the context, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity, prevents H3K4me demethylase activity of KDM1A, thereby acting as a coactivator or a corepressor, via histone deacetylase (HDAC) recruitment, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms KIAA0601 BHC110 LSD1
Also known asKDM1A Polyclonal Antibody
Other nameAnti-KDM1A Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetKDM1A
Short nameAnti-KDM1A (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-KDM1A (polyclonal)
Alternative techniquepolyclonals
Identity 29079
Gene KDM1A
Long gene name lysine demethylase 1A
Synonyms gene AOF2 KDM1
Synonyms gene name amine oxidase (flavin containing) domain 2 lysine (K)-specific demethylase 1
Locus 1p36, 12
Discovery year 2004-02-26
GenBank acession AL031428
Entrez gene record 23028
Pubmed identfication 9628581 12493763
RefSeq identity NM_015013
Classification Lysine demethylases
Havana BLAST/BLAT OTTHUMG00000003220

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