Filters

Anti-lamin A/C (Polyclonal), ALEXA Fluor 594

Anti-lamin A/C (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/Peptidelamin A/C
SpecificityThis antibody reacts specifically with lamin A/C
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human lamin A/C
Gene ID4000
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information A-type lamins and B-type lamins, Besides interactions with the nuclear membrane and other intermediate filaments, Eukaryotic chromatin is organised into loops, Lamins, Many biochemical and molecular features of lamins have been studied, Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane, One of the functions ascribed to the lamina is the maintenance of the structural integrity of the nucleus, The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, The nuclear lamins comprise a unique subclass of the intermediate filament protein family, They share a molecular domain organisation with the other intermediate filament proteins in that they are fibrous molecules that have an aminoterminal globular head, This organisation is thought to contribute to compaction of the chromatin and regulation of gene expression, Two main subtypes of nuclear lamins can be distinguished, a central rod of a-helices and a carboxyterminal globular domain, as part of the nuclear matrix, but their functions remain still largely undetermined, i, i, i, lamin A, lamin B1 and lamin B2, lamin C and lamin Adel10, lamins interact with the nuclear chromatin, may be involved in these processes since chromatin binding sites have been detected in both A- and B-type lamins, which are attached to the nuclear matrix, while the B-type lamins include two proteins arising from two distinct genes, Nuclear Envelope Marker An important part of the cell nucleus is formed by nuclear lamina, e, e, e
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms HGPS MADA LMNA
Also known aslamin A/C Polyclonal Antibody
Other nameAnti-lamin A/C Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetlamin A/C
Short nameAnti-lamin A/C (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-lamin A/C (polyclonal)
Alternative techniquepolyclonals
Identity 9450
Gene PRO1
Long gene name lamin A/C
Synonyms gene LMN1 CMD1A LGMD1B LMNL1
Synonyms gene name cardiomyopathy, dilated 1A (autosomal dominant) limb girdle muscular dystrophy 1B (autosomal dominant) progeria 1 (Hutchinson-Gilford type) lamin A/C-like 1
Synonyms name mandibuloacral dysplasia type A
Locus 1q22
Discovery year 1992-04-09
GenBank acession BC014507
Entrez gene record 4000
Pubmed identfication 8511676 8838815 12702809
RefSeq identity NM_170707
Classification Lamins
Havana BLAST/BLAT OTTHUMG00000013961
Locus Specific Databases Inherited Peripheral Neuropathies Mutation Database Leiden Muscular Dystrophy Pages UMD Locus Specific Databases Leiden Muscular Dystrophy pages LRG_254

Similar products

Subscribe to our Newsletter