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Anti-LGR5 Antibody

Anti-LGR5 Antibody size: 0.4 ml 406

Supplier NJS POLY
Price 406
Size 0.4 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormPurified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenAnti-LGR5
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, WB, IHC
Recommended dilutionsIHC (Paraffin): 1:10-1:50, Western blot: 1:1000
NotesTitration of the anti-LGR5 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis anti-LGR5 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #O75473
PurityPurified
Description In contrast to classical G-protein coupled receptors, Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development, RSPO2, RSPO3 or RSPO4), Upon binding to R-spondins (RSPO1, [UniProt], associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, does not activate heterotrimeric G-proteins to transduce the signal, triggering the canonical Wnt signaling pathway to increase expression of target genes, LGR5/GPR49 is a receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle
ImmunogenA portion of amino acids 605-638 from the human protein was used as the immunogen for this anti-LGR5 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the anti-LGR5 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetLGR5
Short nameAnti-LGR5 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameantibody to-LGR5 (Antibody to)
Alternative techniqueantibodies
Identity 4504
Gene LGR5
Long gene name leucine rich repeat containing G protein-coupled receptor 5
Synonyms gene GPR67 GPR49
Synonyms gene name G protein-coupled receptor 49
Synonyms HG38 FEX
Locus 12q21, 1
Discovery year 1999-10-22
GenBank acession AF062006
Entrez gene record 8549
Pubmed identfication 9642114
RefSeq identity NM_003667
Classification Class A orphans , G protein-coupled receptors
Havana BLAST/BLAT OTTHUMG00000169543

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