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Anti-MAPKAPK5(Thr182) (Polyclonal), ALEXA Fluor 594

Anti-MAPKAPK5(Thr182) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 516
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideMAPKAPK5 Thr182
SpecificityMAPKAPK5(Thr182), This phosphorylation site is homologous to that of Thr182 in Mouse
ModificationPhosphorylation
Modification siteThr182
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locations Nucleus, Cytoplasm
Antigen SourceKLH conjugated synthetic phosphopeptide derived from human MAPKAPK5 around the phosphorylation site of Thr182
Gene ID8550
Swiss ProtQ8IW41
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation, Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB, Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53, ERK3/MAPK6, ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, ERK4/MAPK4, HSP27/HSPB1, Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, Phosphorylates FOXO3, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), enabling expression of miR-34b and miR-34c, inducing F-actin rearrangement, p53/TP53 and RHEB, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4), Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms PRAK
Also known asMAPKAPK5(Thr182) Polyclonal Antibody
Other nameAnti-MAPKAPK5(Thr182) Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetMAPKAPK5(Thr182)
Short nameAnti-MAPKAPK5(Thr182) (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-MAPKAPK5(Thr182) (polyclonal)
Alternative techniquepolyclonals
Identity 6889
Gene MAPKAPK5
Long gene name mitogen-activated protein kinase-activated protein kinase 5
Locus 12q24, 12-q24, 13
Discovery year 1999-03-26
GenBank acession AF032437
Entrez gene record 8550
Pubmed identfication 9628874
RefSeq identity NM_139078
Classification Mitogen-activated protein kinase-activated protein kinases
Havana BLAST/BLAT OTTHUMG00000169605

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