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Anti-MKK3(Ser218)/MKK6(Ser207) , ALEXA Fluor 594

Anti-MKK3(Ser218)/MKK6(Ser207) , ALEXA Fluor 594 size: 100 microliters 516

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 516
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideMKK3 Ser218 + MKK6 Ser207
Specificity and homologous across the listed species in MKK6, MKK3(Ser218)/MKK6(Ser207), This phosphorylation site is homologous in Mouse and homologous to that of Ser290 in Rat in MKK3
ModificationPhosphorylation
Modification siteSer207
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locations Membrane bound, Nucleus, Cytoplasm
Antigen SourceKLH conjugated synthetic phosphopeptide derived from human MKK3 around the phosphorylation site of Ser218
Gene ID5606, 5608
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, It phosphorylates and thus activates MAPK14/p38-MAPK, Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene, The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis, This kinase can be activated by insulin, This kinase is activated by mitogenic and environmental stress, and confers oncogenic transformation of primary cells, and is necessary for the expression of glucose transporter, and participates in the MAP kinase-mediated signaling cascade, which thus leads to the constitutive activation of MAPK14, The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms MEK6 MKK6 SAPKK3 MAPKK6
Also known asMKK3(Ser218)/MKK6(Ser207) Antibody
Other nameAnti-MKK3(Ser218)/MKK6(Ser207)
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetMKK3(Ser218)/MKK6(Ser207)
Short nameAnti-MKK3(Ser218)/MKK6(Ser207) Fluor 594
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-MKK3(Ser218)/MKK6(Ser207)
Identity 6846
Gene MAP2K6
Long gene name mitogen-activated protein kinase kinase 6
Synonyms gene PRKMK6
Synonyms name kinase 6 (MAP kinase kinase 6) , mitogen-activated, protein kinase
Locus 17q24, 3
Discovery year 1997-11-11
GenBank acession U39064
Entrez gene record 5608
Pubmed identfication 8621675
RefSeq identity NM_002758
Classification Mitogen-activated protein kinase kinases
Havana BLAST/BLAT OTTHUMG00000180311

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