Anti-MMP-14 (Polyclonal), ALEXA Fluor 594

Anti-MMP-14 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Price 489

Size 100 microliters

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Type	Conjugated Primary Antibody
Conjugated with	594, ALEXA FLUOR®
Host organism	Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide	MMP-14
Specificity	This antibody reacts specifically with MMP-14
Modification	No modification has been applied to this antibody
Modification site	None
Clonality	Polyclonal Antibody
Clone	Polyclonal Antibodies
Concentration	1ug per 1ul
Subcellular locations	Extracellular
Antigen Source	KLH conjugated synthetic peptide derived from sheep MMP14
Gene ID	N/A
Swiss Prot	Q9BGL3
Applications	IF(IHC-P)
Applications with corresponding dilutions	IF(IHC-P)(1:50-200)
Cross reactive species	Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details	However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information	Activates progelatinase A, Activates progelatinase A by cleavage of the propeptide at 37-Asn-\|-Leu-38, All MMPs are synthesized as proenzymes, Alzheimer's, Collectively, Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development, In addition, In general, MMP14 is expressed in very low levels and may require stimulation with concanavolin A or the phorbol ester TPA to stimulate production of MMP14, MMPs are considered to play an important role in wound healing, Matrix metalloproteinase-14 precursor is endopeptidase that degrades various components of the extracellular matrix, Thus, [Catalytic activity] Endopeptidase activity, a hinge region, a propeptide, a signal peptide, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs, and in cancer cell invasion and metastasis, and in diseases such as multiple sclerosis, and most of them are secreted from the cells as proenzymes, angiogenesis and tissue remodeling, apoptosis, arthritis, atherosclerosis, bone elongation, embryo development, fibronectin, fibronectin like repeats, gelatinase, glumerulonephritis, including fibrillar and non fibrillar collagens, laminin and basement membrane glycoproteins, lupus, malignant gliomas, periodontis, stomelysin and membrane-type MMP subfamilies, such as collagen, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown, these enzymes can degrade all the components of the extracellular matrix, tissue ulceration, uterine involution, MMP14 may be an activator of pro gelatinase A and is expressed in fibroblast cells during both wound healing and human cancer progression, The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases
Purification method	Purified by Protein A
Storage	50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission	590nm/617nm
Synonyms	MMP-X1, MMP14, MMP14_HUMAN, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, Membrane-type matrix metalloproteinase 1, Membrane-type-1 matrix metalloproteinase, MMP-14
Also known as	MMP-14 Polyclonal Antibody
Other name	Anti-MMP-14 Polyclonal
Advisory	For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
Properties	For facs or microscopy Alexa 1 conjugate
Conjugation	Alexa Fluor
Group	Polyclonals and antibodies
About	The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene target	MMP-14
Short name	Anti-MMP-14 (Polyclonal) Fluor 594
Technique	Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different
Label	ALEXA
Alternative name	ALEXA Fluor 594, antibody to-MMP-14 (polyclonal)
Alternative technique	polyclonals

Anti-MMP-14 (Polyclonal), ALEXA Fluor 594

Anti-MMP-14 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

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