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Anti-MOUSE BLNK

Anti-MOUSE BLNK size: 100ug 486

Supplier MBS POLYCLONALS 1
Price 486
Size 100ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Alternative name1Anti-RABBIT ANTI MOUSE BLNK
Alternative name2RABBIT ANTI Murine BLNK
Alternative name3Lapin ANTI Mus musculus BLNK
Alternative name4BLNK
Alternative name5N/A
Other names B cell linker, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, B-cell adapter containing a Src homology 2 domain protein, B-cell linker protein, B-cell linker protein, Cytoplasmic adapter protein, Lymphocyte antigen 57, Src homology 2 domain-containing leukocyte protein of 65 kDa, cytoplasmic adapter protein, lymphocyte antigen 57, src homology 2 domain-containing leukocyte protein of 65 kDa, B-cell linker protein
Gene nameBLNK
Gene name synonimsN/A
Other gene names BASH, Bash, Bca, Blnk, Ly-57, Ly57, Ly57, Lyw-57, SLP-65, Slp-65, Slp65, Blnk
CategoryAntibodies
ClonalityPolyclonal
Immunoglobulin isotypePolyclonal IgG
ClonePolyclonal antibody
Host organismRabbit
Species reactivityMouse
Specificity and cross-reactivity PLC gamma and the adaptor proteins Crb2 and Nck, The resulting tyrosine phosphorylation of BLNK by syk, _x000D__x000D_BLNK plays a pivotal role in B cell activation through cross-linkage of the B-cell Receptor (BCR), a cytosolic adaptor molecule, differentiation and apoptosis, leading to the activation of protein tyrosine kinases (PTKs) including syk, provides docking sites for the SH2-containing effector molecules such as Vav, thereby acting as a central linker protein in many different B cell signalling pathways involved in proliferation, visualised as two phosphoproteins of 68 and 70kDa in SDS/PAGE, BLNK This item recognises B-cell Linker Protein (BLNK)
Purification methodN/A
Form/AppearancePurified (Purified IgG - liquid)
Concentration0 mg/ml, Ig concentration 1
Storage and shipping Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius
Tested for:Western Blot (WB)
Description Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged
Gene targetBLNK
Short nameAnti-MOUSE BLNK
Alternative nameantibody to-MOUSE B-cell linker
Alternative to gene target BLNK and IDBG-83724 and ENSG00000095585 and 29760, BT, Blnk and IDBG-165316 and ENSMUSG00000061132 and 17060, Plasma membranes, protein binding, this GO :0005068 and transmembrane receptor protein tyrosine kinase adaptor activity and molecular function this GO :0005070 and SH3/SH2 adaptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006954 and inflammatory response and biological process this GO :0006959 and humoral immune response and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0009967 and positive regulation of signal transduction and biological process this GO :0030183 and B cell differentiation and biological process this GO :0035556 and intracellular signal transduction and biological process, this GO :0005068: transmembrane receptor protein tyrosine kinase adaptor activity, this GO :0005068: transmembrane receptor protein tyrosine kinase adaptor activity and also this GO :0005070: SH3/SH2 adaptor activity and also this GO :0005515: protein binding, this GO :0005070: SH3/SH2 adaptor activity, this GO :0005515: protein binding, 24520 and IDBG-638042 and ENSBTAG00000021358 and 510393, B-cell linker
Identity 14211
Gene BLNK
Long gene name B-cell linker
Synonyms SLP65 Ly57 SLP-65 BLNK-s BASH bca
Synonyms name B-cell adapter containing a SH2 domain protein B-cell activation Src homology [SH2] domain-containing leukocyte protein of 65 kD B cell adaptor containing SH2 domain
Locus 10q24, 1
Discovery year 2001-07-16
GenBank acession AF068180
Entrez gene record 29760
Pubmed identfication 9697839 10583958
RefSeq identity NM_013314
Classification SH2 domain containing
Havana BLAST/BLAT OTTHUMG00000018827
Locus Specific Databases BLNKbase: Mutation registry for BLNK deficiency LRG_21

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