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Anti-MOUSE DELTA-LIKE PROTEIN 3

Anti-MOUSE DELTA-LIKE PROTEIN 3 size: 100ug 459

Supplier MBS POLYCLONALS 1
Price 459
Size 100ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Alternative name1Anti-RABBIT ANTI MOUSE DELTA-LIKE PROTEIN 3
Alternative name2RABBIT ANTI Murine DELTA-LIKE PROTEIN 3
Alternative name3Lapin ANTI Mus musculus DELTA-LIKE PROTEIN 3
Alternative name4DELTA-LIKE PROTEIN 3
Alternative name5N/A
Other names Delta-like protein 3, Drosophila Delta homolog 3, delta-like 3 (Drosophila), delta-like protein 3, delta3, drosophila Delta homolog 3, delta-like protein 3 isoform 1
Gene nameN/A
Gene name synonimsN/A
Other gene names DLL3, Delta3, SCDO1, DLL3
CategoryAntibodies
ClonalityPolyclonal
Immunoglobulin isotypePolyclonal IgG
ClonePolyclonal antibody
Host organismRabbit
Species reactivityMouse
Specificity and cross-reactivity DLL3 acts as a regulator of Notch 1, DLL3 and DLL4, Delta like-1 (DLL1), Jagged1 (CD339), Jagged2, More than 25 mutations in the DLL3 gene are known to be responsible for the autosomal recessive skeletal malformation condition known as spondylocostal dysostosis type 1 (SCDO1), Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), The canonical pathway inhibits the differentiation of stem cells or progenitor cells, _x000D__x000D_DLL3 is predominantly expressed in the neuroectoderm and paraxial mesoderm during embryogenesis, _x000D__x000D_Ligation of Notch receptors by their specific ligands, _x000D__x000D_The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, and both tumour progression and suppression, and developmental defects, and studies in mice have linked DLL3-Notch signalling with liver regeneration, as an inhibitor of primary neurogenesis, associated with vertebral and rib segmentation defects, cardiac and endocrine development, during early development, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, on physically adjacent signal receiving cells, one of the five major ligands of the Notch signalling pathway, or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway), releasing the Notch intracellular domain (NICD) to translocate to the nucleus, stem cell haematopoiesis, thymic T-cell development, where it plays a role in somite segmentation, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4, which is vital for cell-cell communication, whilst the non-canonical pathway promotes differentiation, within the transmembrane domain, DELTA-LIKE PROTEIN 3 This antibody recognises mouse Delta-like protein 3 (DLL3), _x000D_
Purification methodN/A
Form/AppearancePurified (Purified IgG - liquid)
Concentration0mg/ml, IgG concentration 1
Storage and shipping Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius
Tested for: Western Blot (WB), ELISA (EIA)
Description Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged
Gene targetDELTA-LIKE PROTEIN 3
Short nameAnti-MOUSE DELTA-LIKE PROTEIN 3
Alternative nameantibody to-MOUSE DELTA-LIKE PROTEIN 3

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