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Anti-MTM1 (Polyclonal), ALEXA Fluor 594

Anti-MTM1 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideMTM1
SpecificityThis antibody reacts specifically with MTM1
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human MTM1/Myotubularin
Gene ID4534
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Human MTM1, Myotubularin is primarily a lipid phosphatase that acts on phosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI3-kinase) pathway and membrane trafficking, The gene for MTM1 is localized to a 300 kb critical region on human Xq128 between IDS and GRBRA3, The gene responsible for myotubular myopathy MTM1 encodes a dual specificity phosphatase, The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-Tooth neuropathy, Thus, Wild-type myotubularin can directly dephosphorylate PI3P and PI4P in vitro, a 603 amino-acid protein, in most cases, is mutated in myotubular myopathy, it decreases PI3P levels by down-regulating PI3K activity and by facilitating the degradation of PI3P, leads to early postnatal death, named myotubularin, which is highly conserved through evolution, X-linked recessive myotubular myopathy is a congenital muscular disease characterized by severe hypotonia and generalized muscle weakness that
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Also known asMTM1 Polyclonal Antibody
Other nameAnti-MTM1 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetMTM1
Short nameAnti-MTM1 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-MTM1 (polyclonal)
Alternative techniquepolyclonals
Identity 7448
Gene MTM1
Long gene name myotubularin 1
Synonyms gene name myotubular myopathy 1
Locus Xq28
Discovery year 2001-06-22
GenBank acession U46024
Entrez gene record 4534
RefSeq identity NM_000252
Classification Phosphoinositide phosphatases Myotubularins
Havana BLAST/BLAT OTTHUMG00000024158
Locus Specific Databases Leiden Muscular Dystrophy pages Mental Retardation database LRG_839

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