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Anti-NFAT5 (Ser1197) (Polyclonal), ALEXA Fluor 594

Anti-NFAT5 (Ser1197) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 516
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideNFAT5 Ser1197
SpecificityThis antibody reacts specifically with NFAT5 (Ser1197)
ModificationPhosphorylation
Modification siteSer1197
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic phosphopeptide derived from human NFAT5 around the phosphorylation site of Ser1197
Gene ID10725
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Fos and Jun, In addition to activating cytokine gene transcription, NFAT proteins are activated by increases in intracellular calcium, NFAT proteins are widely expressed and alternatively modified to generate splice variants, NFAT1, NFAT2, NFAT2 is also implicated in cardiac valve development, NFAT5 is detected in both immune and nonimmune cells and, This activating event induces a conformational change in the protein structure that exposes the nuclear localization signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues, and NFAT3 is involved in cardiac hypertrophy, and NFAT4 are predominantly expressed in immune cells, and they are localized to both the cytosol (NFATc) and to the nucleus (NFATn), calcineurin, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA, dephosphorylating NFAT proteins, like other NFAT proteins, on DNA to regulate cytokine expression in T cells, which leads to the calmodulin-dependent phosphatase, Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms TONEBP KIAA0827 NFATL1 OREBP NFATZ NF-AT5
Also known asNFAT5 (Ser1197) Polyclonal Antibody
Other nameAnti-NFAT5 (Ser1197) Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetNFAT5 (Ser1197)
Short nameAnti-NFAT5 (Ser1197) (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, tonicity-responsive (Ser1197) (polyclonal), antibody to-nuclear factor on activated T-cells 5
Alternative techniquepolyclonals
Alternative to gene target DNA-templated and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0007165 and signal transduction and biological process this GO :0007588 and excretion and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0045087 and innate immune response and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0070884 and regulation of calcineurin-NFAT signaling cascade and biological process, NF-AT5 and NFATL1 and NFATZ and OREBP and TONEBP, NFAT5 and IDBG-39265 and ENSG00000102908 and 10725, NFAT5 and IDBG-634541 and ENSBTAG00000013412 and 538523, Nfat5 and IDBG-190689 and ENSMUSG00000003847 and 54446, nuclei, protein binding, this GO :0001816 and cytokine production and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006355 and regulation of transcription, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0005515: protein binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0005515: protein binding, tonicity-responsive, nuclear factor of activated T-cells 5
Identity 7774
Gene NFAT5
Long gene name nuclear factor of activated T-cells 5
Synonyms gene name nuclear factor of activated T-cells 5, tonicity-responsive
Synonyms name tonicity-responsive enhancer binding protein
Locus 16q22, 1
Discovery year 1999-07-16
GenBank acession AF134870
Entrez gene record 10725
Pubmed identfication 10377394
RefSeq identity NM_138714
Classification Nuclear factors of activated T-cells
Havana BLAST/BLAT OTTHUMG00000137572

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