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Anti-NKCC1 (Polyclonal), ALEXA Fluor 594

Anti-NKCC1 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideNKCC1
SpecificityThis antibody reacts specifically with NKCC1
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsExtracellular
Antigen SourceKLH conjugated synthetic peptide derived from human NKCC1
Gene IDN/A
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information In mice, In the basolateral membrane of secretory epithelia, Mutations in the gene encoding NCCT cause Gitelmanâ, NCCT is a thiazide-sensitive Na-Cl cotransporter that is primarily expressed in the distal convoluted tubule of the kidney where it accounts for a significant fraction of net renal sodium reabsorption, NKCC1 is expressed in muscle cells, NKCC1 mediates active chloride secretion, NKCC2 is sensitive to the clinically important diuretics furosemide and bumetanide, NKCC2 is specifically expressed in the kidney where it mediates active reabsorption of sodium chloride in the thick ascending limb of the loop of Henle, The gene encoding human NKCC1 maps to chromosome 5q23, The gene encoding human NKCC2 maps to chromosome 15q15-q21 and mutations in this gene lead to Bartterâ, The gene for human NCCT map to chromosome 16q13, a subset of Bartterâ, an inherited hypokalaemic alkalosis, and red blood cells, disruption of the NKCC1 gene leads to deafness and impaired balance, neurons, &euro, &euro, &euro, &trade, &trade, &trade, 3, Na-K-Cl cotransporters (NKCC) are channel proteins that aid in the transcellular movement of chloride across both secretory and absorptive epithelia, s syndrome, s syndrome, s syndrome
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms NKCC1 BSC BSC2 PPP1R141
Also known asNKCC1 Polyclonal Antibody
Other nameAnti-NKCC1 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetNKCC1
Short nameAnti-NKCC1 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-NKCC1 (polyclonal)
Alternative techniquepolyclonals
Identity 10911
Gene SLC12A2
Long gene name solute carrier family 12 member 2
Synonyms gene name member 2 , solute carrier family 12 (sodium/potassium/chloride transporter)
Synonyms name bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1 basolateral Na-K-Cl symporter protein phosphatase 1, regulatory subunit 141
Locus 5q23, 3
Discovery year 1994-02-16
Entrez gene record 6558
Pubmed identfication 7629105
RefSeq identity NM_001046
Classification Solute carriers Protein phosphatase 1 regulatory subunits
Havana BLAST/BLAT OTTHUMG00000128983

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