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Anti-NMDAR2B (Tyr1252) (Polyclonal), ALEXA Fluor 594

Anti-NMDAR2B (Tyr1252) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 516
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideNMDAR2B Tyr1252
SpecificityNMDAR2B (Tyr1252), This antibody may cross react with NMDAR2A (Tyr 1246) due to 75% sequence similarity
ModificationPhosphorylation
Modification siteTyr1252
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsCytoplasm
Antigen SourceKLH conjugated synthetic phosphopeptide derived from human NMDAR2B around the phosphorylation site of Tyr1252
Gene ID2904
Swiss ProtQ13224
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information In concert with DAPK1 at extrasynaptic sites, Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, Mediated by glycine, acts as a central mediator for stroke damage, resulting in an irreversible neuronal death (By similarity), NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms GluN2B
Also known asNMDAR2B (Tyr1252) Polyclonal Antibody
Other nameAnti-NMDAR2B (Tyr1252) Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetNMDAR2B (Tyr1252)
Short nameAnti-NMDAR2B (Tyr1252) (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-NMDAR2B (Tyr1252) (polyclonal)
Alternative techniquepolyclonals
Identity 4586
Gene GRIN2B
Long gene name glutamate ionotropic receptor NMDA type subunit 2B
Synonyms gene NMDAR2B
Synonyms gene name N-methyl D-aspartate 2B , glutamate receptor, ionotropic
Locus 12p13, 1
Discovery year 1992-09-18
Entrez gene record 2904
Pubmed identfication 1350383
Classification Glutamate ionotropic receptor NMDA type subunits
Havana BLAST/BLAT OTTHUMG00000137373

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