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Anti-NUMBL (Polyclonal), ALEXA Fluor 594

Anti-NUMBL (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideNUMBL
SpecificityThis antibody reacts specifically with NUMBL
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human NUMBL
Gene IDN/A
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information CAG3A, CTG3a, Expressed at high levels in developing brain tissue, In mice, LNX1 and Notch 1, NBL, NUMBLIKE or TNRC23, NumbL (NUMB-like protein), NumbL contains one PID (phosphotyrosine interaction domain) and plays an important role in neuronal differentiation, The mammalian NUMB homolog plays a role in the determination of cell fate during development and binds with a variety of proteins, a signaling adapter protein with two protein-protein interaction domains, also known as Numb-R, deletion of the NumbL gene is associated with early embryonic death, including Eps15, is a 609 amino acid cytoplasmic protein that, is thought to play a role in cell fate, like NUMB, namely a phosphotyrosine-binding domain and a proline-rich SH3-binding region (PRR), neuronal cell fate decisions are directed by NUMB, possibly associating with Eps15 and Notch 1, suggesting an essential role for NumbL in early development, In Drosophila
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms NUMB-R CTG3a CAG3A TNRC23 NUMBR NUMBLIKE
Also known asNUMBL Polyclonal Antibody
Other nameAnti-NUMBL Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetNUMBL
Short nameAnti-NUMBL (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-numb homolog (Drosophila)-like (polyclonal)
Alternative techniquepolyclonals
Alternative to gene target CAG3A and CTG3a and NBL and NUMB-R and NUMBLIKE and NUMBR and TNRC23, Cytoplasm, NUMBL and IDBG-52025 and ENSG00000105245 and 9253, NUMBL and IDBG-638153 and ENSBTAG00000019461 and 510973, Numbl and IDBG-160322 and ENSMUSG00000063160 and 18223, protein binding, this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0007399 and nervous system development and biological process this GO :0007405 and neuroblast proliferation and biological process this GO :0007409 and axonogenesis and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019538 and protein metabolic process and biological process this GO :0021670 and lateral ventricle development and biological process this GO :0021849 and neuroblast division in subventricular zone and biological process this GO :0030900 and forebrain development and biological process this GO :0034332 and adherens junction organization and biological process this GO :0045087 and innate immune response and biological process this GO :0050769 and positive regulation of neurogenesis and biological process this GO :0050775 and positive regulation of dendrite morphogenesis and biological process, this GO :0005515: protein binding, this GO :0005515: protein binding, numb homolog (Drosophila)-like
Identity 8061
Gene NUMBL
Long gene name NUMB like, endocytic adaptor protein
Synonyms gene name numb (Drosophila) homolog-like
Locus 19q13, 2
Discovery year 1999-03-12
GenBank acession AF015401
Entrez gene record 9253
Pubmed identfication 9225980 9303539
RefSeq identity NM_004756
Classification Trinucleotide repeat containing
Havana BLAST/BLAT OTTHUMG00000182627

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