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Anti-p73(Tyr99) (Polyclonal), ALEXA Fluor 594

Anti-p73(Tyr99) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

Price 516
Size 100 microliters
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/Peptidep73 Tyr99
SpecificityThis antibody reacts specifically with p73(Tyr99)
ModificationPhosphorylation
Modification siteTyr99
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic phosphopeptide derived from human p73 around the phosphorylation site of Tyr99 [SP(p-Y)AQ]
Gene ID7161
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Alternative splicing of the proto-oncogene H-ras pre-mRNA has led to two distinct transcripts, However, In this study, In this study, Oncogenic MDM2 (mouse double minutes 2) is a known repressor of p73 transcriptional activity, Ras proteins are known to be small membrane-localized guanine nucleotide-binding proteins, The p73 protein, Therefore, a tumor suppressor gene, by the yeast two-hybrid screening method, involving p19ras and p73, it further inhibited the association of MDM2 to the p73 protein, p19ras, p19ras is localized in the nucleus and the cytosol and its interaction with P73 protein occurred exclusively in the nucleus, this study presents a novel pathway of Ras signaling that occurs in the nucleus, unlike other Ras proteins, when p19ras was bound to MDM2, P73 protein is a structural and functional homologue of p53
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms P73_HUMAN, TP 73, TP73, TP73phospho Y99, Tumor Protein p73, p53 Related Protein, p53 like transcription factor, p73, p73Tyr99
Also known asp73(Tyr99) Polyclonal Antibody
Other nameAnti-p73(Tyr99) Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetp73(Tyr99)
Short nameAnti-p73(Tyr99) (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-p73(Tyr99) (polyclonal)
Alternative techniquepolyclonals

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