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Anti-PHD2 (Polyclonal), ALEXA Fluor 594

Anti-PHD2 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptidePHD2
SpecificityThis antibody reacts specifically with PHD2
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locations Nucleus, Cytoplasm
Antigen SourceKLH conjugated synthetic peptide derived from human PHD2
Gene ID54583
Swiss ProtQ9GZT9
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Also hydroxylates HIF2A, CODD) of HIF1A, EGLN1 is the most important isozyme under normoxia and, Has a preference for the CODD site for both HIF1A and HIF1B, Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex, Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, Target proteins are preferencially recognized via a LXXLAP motif, Under hypoxic conditions, and C-terminal, and increased expression of hypoxy-inducible genes, heterodimerization with HIF1B, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins, through regulating the stability of HIF1, under normoxic conditions, Cellular oxygen sensor that catalyzes
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms SM-20 PHD2 ZMYND6 HIFPH2
Also known asPHD2 Polyclonal Antibody
Other nameAnti-PHD2 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetPHD2
Short nameAnti-PHD2 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-PHD2 (polyclonal)
Alternative techniquepolyclonals
Identity 1232
Gene EGLN1
Long gene name egl-9 family hypoxia inducible factor 1
Synonyms gene C1orf12
Synonyms gene name EGL nine (C, elegans) egl-9 family hypoxia-inducible factor 1 , elegans) homolog 1 egl nine homolog 1 (C
Synonyms name HIF prolyl hydroxylase 2
Locus 1q42, 2
Discovery year 2000-06-16
GenBank acession AJ310543
Entrez gene record 54583
Pubmed identfication 11056053
RefSeq identity NM_022051
Classification Zinc fingers MYND-type
Havana BLAST/BLAT OTTHUMG00000038027

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