Name : Anti-PLCG2(Tyr1217) (Polyclonal), ALEXA Fluor 594
Supplier : BIOSS POLYCLONAL ANTIBODIES
Price :516
SKU : GEN1523691812
| Type | Conjugated Primary Antibody |
| Conjugated with | 594, ALEXA FLUOR® |
| Host organism | Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide | PLCG2Tyr1217 |
| Specificity | This antibody reacts specifically with PLCG2(Tyr1217) |
| Modification | Phosphorylation |
| Modification site | Tyr1217 |
| Clonality | Polyclonal Antibody |
| Clone | Polyclonal Antibodies |
| Concentration | 1ug per 1ul |
| Subcellular locations | N/A |
| Antigen Source | KLH conjugated synthetic phosphopeptide derived from human PLC gamma 2 around the phosphorylation site of Tyr1217 |
| Gene ID | 5336 |
| Swiss Prot | N/A |
| Applications | IF(IHC-P) |
| Applications with corresponding dilutions | IF(IHC-P)(1:50-200) |
| Cross reactive species | Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details | However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information | A number of these enzymes have specificity for phosphoinositides, C beta is regulated by heterotrimeric G protein coupled receptors, Of the phosphoinositide specific phospholipase C enzymes, SH2 and SH3, The C gamma 1 and C gamma 2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, while the closely related C gamma 1 and C gamma 2 enzymes are controlled by receptor tyrosine kinases, Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water soluble phosphorylated derivatives of the lipid head groups |
| Purification method | Purified by Protein A |
| Storage | 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission | 590nm/617nm |
| Also known as | PLCG2(Tyr1217) Polyclonal Antibody |
| Other name | Anti-PLCG2(Tyr1217) Polyclonal |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties | For facs or microscopy Alexa 1 conjugate |
| Conjugation | Alexa Fluor |
| Group | Polyclonals and antibodies |
| About | The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target | PLCG2(Tyr1217) |
| Short name | Anti-PLCG2(Tyr1217) (Polyclonal) Fluor 594 |
| Technique | Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different  |
| Label | ALEXA |
| Alternative name | ALEXA Fluor 594, gamma 2 (phosphatidylinositol-specific)(Tyr1217) (polyclonal), antibody to-phospholipase C |
| Alternative technique | polyclonals |
| Alternative to gene target | APLAID and FCAS3 and PLC-gamma-2 and PLC-IV, PLCG2 and IDBG-43723 and ENSG00000197943 and 5336, PLCG2 and IDBG-629513 and ENSBTAG00000002103 and 100337091, Plasma membranes, Plcg2 and IDBG-195070 and ENSMUSG00000034330 and 234779, gamma 2 (phosphatidylinositol-specific), phosphoric diester hydrolase activity, this GO :0002316 and follicular B cell differentiation and biological process this GO :0004435 and phosphatidylinositol phospholipase C activity and molecular function this GO :0004629 and phospholipase C activity and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006629 and lipid metabolic process and biological process this GO :0006661 and phosphatidylinositol biosynthetic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007596 and blood coagulation and biological process this GO :0008081 and phosphoric diester hydrolase activity and molecular function this GO :0009395 and phospholipid catabolic process and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0016055 and Wnt signaling pathway and biological process this GO :0019722 and calcium-mediated signaling and biological process this GO :0030168 and platelet activation and biological process this GO :0030183 and B cell differentiation and biological process this GO :0032237 and activation of store-operated calcium channel activity and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032959 and inositol trisphosphate biosynthetic process and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038096 and Fc-gamma receptor signaling pathway involved in pha this GO cytosis and biological process this GO :0043069 and negative regulation of programmed cell death and biological process this GO :0043647 and inositol phosphate metabolic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0045087 and innate immune response and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0050853 and B cell receptor signaling pathway and biological process this GO :0051209 and release of sequestered calcium ion into cytosol and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0004435: phosphatidylinositol phospholipase C activity, this GO :0004435: phosphatidylinositol phospholipase C activity and also this GO :0004629: phospholipase C activity and also this GO :0004871: signal transducer activity and also this GO :0005515: protein binding and also this GO :0008081: phosphoric diester hydrolase activity, this GO :0004629: phospholipase C activity, this GO :0004871: signal transducer activity, this GO :0005515: protein binding, this GO :0008081: phosphoric diester hydrolase activity, phospholipase C |
| Identity | 9066 |
| Gene | PLCG2 |
| Long gene name | phospholipase C gamma 2 |
| Synonyms gene name | gamma 2 (phosphatidylinositol-specific) , phospholipase C |
| Locus | 16q24, 1 |
| Discovery year | 1994-05-16 |
| Entrez gene record | 5336 |
| Pubmed identfication | 7835906 |
| Classification | Phospholipases SH2 domain containing C2 domain containing phospholipases |
| Havana BLAST/BLAT | OTTHUMG00000176532 |
| Locus Specific Databases | LRG_376 |