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Anti-presenilin 1 (Polyclonal), ALEXA Fluor 594

Anti-presenilin 1 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismMouse (Mus musculus)
Target Protein/Peptidepresenilin 1
SpecificityThis antibody reacts specifically with presenilin 1
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsCytoplasm
Antigen SourceKLH conjugated synthetic peptide derived from rat presenilin 1
Gene ID29192
Swiss ProtP97887
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Rabbit, Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information May also play a role in hematopoiesis (By similarity), May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane, Requires the other members of the gamma-secretase complex to have a protease activity, Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex, Under conditions of apoptosis or calcium influx, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein), cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling, Probable catalytic subunit of the gamma-secretase complex
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms PRO2207 PSARL1 RHBDS1
Also known aspresenilin 1 Polyclonal Antibody
Other nameAnti-presenilin 1 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetpresenilin 1
Short nameAnti-presenilin 1 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-presenilin 1 (polyclonal)
Alternative techniquepolyclonals
Identity 18253
Gene PARL
Long gene name presenilin associated rhomboid like
Synonyms gene PSARL
Synonyms gene name presenilin associated, rhomboid-like
Synonyms name rhomboid 7 homolog 1 (Drosophila)
Locus 3q27, 1
Discovery year 2003-09-03
GenBank acession AF116692
Entrez gene record 55486
RefSeq identity NM_018622
Classification Rhomboid family
Havana BLAST/BLAT OTTHUMG00000156890

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