Name : Anti-RAD51(Tyr315) (Polyclonal), ALEXA Fluor 594
Supplier : BIOSS POLYCLONAL ANTIBODIES
Price :516
SKU : GEN7514216480
| Type | Conjugated Primary Antibody |
| Conjugated with | 594, ALEXA FLUOR® |
| Host organism | Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide | RAD51 Tyr315 |
| Specificity | This antibody reacts specifically with RAD51(Tyr315) |
| Modification | Phosphorylation |
| Modification site | Tyr315 |
| Clonality | Polyclonal Antibody |
| Clone | Polyclonal Antibodies |
| Concentration | 1ug per 1ul |
| Subcellular locations | N/A |
| Antigen Source | KLH conjugated synthetic phosphopeptide derived from human RAD51 around the phosphorylation site of Tyr315 |
| Gene ID | 5888 |
| Swiss Prot | N/A |
| Applications | IF(IHC-P) |
| Applications with corresponding dilutions | IF(IHC-P)(1:50-200) |
| Cross reactive species | Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details | However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information | BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein, Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis, RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, This protein can interact with the ssDNA-binding protein RPA and RAD52, This protein is also found to interact with BRCA1 and BRCA2, Transcript variants utilizing alternative polyA signals exist, Two alternatively spliced transcript variants of this gene, and are known to be involved in the homologous recombination and repair of DNA, and it is thought to play roles in homologous pairing and strand transfer of DNA, have been reported, which encode distinct proteins, which may be important for the cellular response to DNA damage, The protein encoded by this gene is a member of the RAD51 protein family |
| Purification method | Purified by Protein A |
| Storage | 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission | 590nm/617nm |
| Synonyms | HsRad51 HsT16930 BRCC5 FANCR |
| Also known as | RAD51(Tyr315) Polyclonal Antibody |
| Other name | Anti-RAD51(Tyr315) Polyclonal |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties | For facs or microscopy Alexa 1 conjugate |
| Conjugation | Alexa Fluor |
| Group | Polyclonals and antibodies |
| About | The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target | RAD51(Tyr315) |
| Short name | Anti-RAD51(Tyr315) (Polyclonal) Fluor 594 |
| Technique | Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different  |
| Label | ALEXA |
| Alternative name | ALEXA Fluor 594, antibody to-RAD51(Tyr315) (polyclonal) |
| Alternative technique | polyclonals |
| Identity | 9817 |
| Gene | RAD51 |
| Long gene name | RAD51 recombinase |
| Synonyms gene | RAD51A RECA |
| Synonyms gene name | E, RAD51 (S, cerevisiae) , cerevisiae) RAD51 homolog (S, cerevisiae) homolog (E coli RecA homolog) RAD51 homolog (RecA homolog, coli) (S |
| Synonyms name | BRCA1/BRCA2-containing complex, subunit 5 |
| Locus | 15q15, 1 |
| Discovery year | 1993-05-26 |
| GenBank acession | D13804 |
| Entrez gene record | 5888 |
| Pubmed identfication | 8358431 8479919 26253028 |
| RefSeq identity | NM_002875 NM_133487 |
| Classification | Fanconi anemia complementation groups |
| Havana BLAST/BLAT | OTTHUMG00000130067 |