Anti-RAGE (Polyclonal), ALEXA Fluor 594

Anti-RAGE (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Price 489

Size 100 microliters

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Type	Conjugated Primary Antibody
Conjugated with	594, ALEXA FLUOR®
Host organism	Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide	RAGE
Specificity	This antibody reacts specifically with RAGE
Modification	No modification has been applied to this antibody
Modification site	None
Clonality	Polyclonal Antibody
Clone	Polyclonal Antibodies
Concentration	1ug per 1ul
Subcellular locations	Extracellular
Antigen Source	KLH conjugated synthetic peptide derived from rat AGER
Gene ID	81722
Swiss Prot	Q63495
Applications	IF(IHC-P), FCM
Applications with corresponding dilutions	IF(IHC-P)(1:50-200), FCM(1:20-100)
Cross reactive species	Rat (Rattus norvegicus)
Cross Reactive Species details	However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information	ABPP-initiated RAGE signaling, AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes, Can also bind oligonucleotides (By similarity), Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons, Interaction with S1A12 on endothelium, Interaction with S1B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling, Receptor for amyloid beta peptide, These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes, and endothelial dysfunction in type 2 diabetes, and lymphocytes triggers cellular activation, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space, mononuclear phagocytes, oxidative stress, with generation of key proinflammatory mediators, Mediates interactions of advanced glycosylation end products (AGE)
Purification method	Purified by Protein A
Storage	50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission	590nm/617nm
Synonyms	RAGE SCARJ1
Also known as	RAGE Polyclonal Antibody
Other name	Anti-RAGE Polyclonal
Advisory	For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
Properties	For facs or microscopy Alexa 1 conjugate
Conjugation	Alexa Fluor
Group	Polyclonals and antibodies
About	The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene target	RAGE
Short name	Anti-RAGE (Polyclonal) Fluor 594
Technique	Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different
Label	ALEXA
Alternative name	ALEXA Fluor 594, antibody to-RAGE (polyclonal)
Alternative technique	polyclonals
Identity	320
Gene	AGER
Long gene name	advanced glycosylation end-product specific receptor
Synonyms name	receptor for advanced glycation end-products
Locus	6p21, 32
Discovery year	1994-10-17
GenBank acession	M91211
Entrez gene record	177
Pubmed identfication	7713518
RefSeq identity	NM_001136
Classification	C2-set domain containing Immunoglobulin like domain containing Scavenger receptors
Havana BLAST/BLAT	OTTHUMG00000031120

Anti-RAGE (Polyclonal), ALEXA Fluor 594

Anti-RAGE (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

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