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Anti-RANK (Polyclonal), ALEXA Fluor 594

Anti-RANK (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideRANK
SpecificityThis antibody reacts specifically with RANK
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsExtracellular
Antigen SourceKLH conjugated synthetic peptide derived from human RANK
Gene IDN/A
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information CD265 is also expressed in dendritic cells, CD265 is widely expressed, Human and murine CD265 share 81% amino acid identity in their extracellular domains, Multiple tumor necrosis factor receptor-associated factors (TRAFs) are involved in the signaling of CD265, RANK and RANK ligand (RANKL) are important regulators of interactions between T cells and dendritic cells, RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis, TRANCE (TNF-related activation-induced cytokines, The binding of anti-CD265 to cell surface CD265 triggers signal transduction and induces CD265 mediated bioactivity, The biological functions mediated by RANK include activation of NFkappaB and cjun N-terminal kinase, The soluble form of CD265 is able to block TRANCE induced biological activity, also known as RANK ligand, colon, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis and lymph node organogenesis, liver, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for CD265, small intestine and adrenal gland, thymus, with highest levels in skeletal muscle, CD265 is a member of the tumor necrosis factor receptor (TNFR) family
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms RANK CD265 FEO
Also known asRANK Polyclonal Antibody
Other nameAnti-RANK Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetRANK
Short nameAnti-RANK (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-RANK (polyclonal)
Alternative techniquepolyclonals
Identity 11908
Gene TNFRSF11A
Long gene name TNF receptor superfamily member 11a
Synonyms gene PDB2 LOH18CR1
Synonyms gene name 18, NFKB activator , activator of NFKB Paget disease of bone 2 loss of heterozygosity, chromosomal region 1 tumor necrosis factor receptor superfamily, member 11a, member 11a, tumor necrosis factor receptor superfamily
Locus 18q21, 33
Discovery year 1998-12-04
GenBank acession AF018253
Entrez gene record 8792
Pubmed identfication 9367155 10615125
Classification CD molecules Tumor necrosis factor receptor superfamily
Havana BLAST/BLAT OTTHUMG00000132779
Locus Specific Databases LRG_194

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