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Anti-RPS3 (Polyclonal), ALEXA Fluor 594
Anti-RPS3 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489
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BIOSS POLYCLONAL ANTIBODIES
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489
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100 microliters
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| Type | Conjugated Primary Antibody |
| Conjugated with | 594, ALEXA FLUOR® |
| Host organism | Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide | RPS3 |
| Specificity | This antibody reacts specifically with RPS3 |
| Modification | No modification has been applied to this antibody |
| Modification site | None |
| Clonality | Polyclonal Antibody |
| Clone | Polyclonal Antibodies |
| Concentration | 1ug per 1ul |
| Subcellular locations | Mitochondrion, Nucleus, Cytoplasm |
| Antigen Source | KLH conjugated synthetic peptide derived from human RPS3 |
| Gene ID | 6188 |
| Swiss Prot | P23396 |
| Applications | IF(IHC-P) |
| Applications with corresponding dilutions | IF(IHC-P)(1:50-200) |
| Cross reactive species | Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details | However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information | Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764), Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744), Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971), Displays high binding affinity for 7, Enhances the uracil excision activity of UNG1 (PubMed:18973764), Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840), Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931), Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413), Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787), Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408), Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002), Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551), Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, Represses its own translation by binding to its cognate mRNA (PubMed:20217897), Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571), When located in the mitochondrion, a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345), enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535), reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537), 8-dihydro-8-oxoguanine (8-oxoG), Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699) |
| Purification method | Purified by Protein A |
| Storage | 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission | 590nm/617nm |
| Synonyms | FLJ26283 FLJ27450 MGC87870 S3 |
| Also known as | RPS3 Polyclonal Antibody |
| Other name | Anti-RPS3 Polyclonal |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties | For facs or microscopy Alexa 1 conjugate |
| Conjugation | Alexa Fluor |
| Group | Polyclonals and antibodies |
| About | The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target | RPS3 |
| Short name | Anti-RPS3 (Polyclonal) Fluor 594 |
| Technique | Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label | ALEXA |
| Alternative name | ALEXA Fluor 594, antibody to-ribosomal protein S3 (polyclonal) |
| Alternative technique | polyclonals |
| Alternative to gene target | RPS3 and IDBG-635601 and ENSBTAG00000005620 and 326588, RPS3 and IDBG-64727 and ENSG00000149273 and 6188, Rps3 and IDBG-200714 and ENSMUSG00000030744 and 27050, S3, endonucleolytic and biological process this GO :0002181 and cytoplasmic translation and biological process this GO :0003684 and damaged DNA binding and molecular function this GO :0003723 and RNA binding and molecular function this GO :0003729 and mRNA binding and molecular function this GO :0003735 and structural constituent of ribosome and molecular function this GO :0003906 and DNA-(apurinic or apyrimidinic site) lyase activity and molecular function this GO :0004519 and endonuclease activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005840 and ribosome and cellular component this GO :0006412 and translation and biological process this GO :0006413 and translational initiation and biological process this GO :0006414 and translational elongation and biological process this GO :0006415 and translational termination and biological process this GO :0006614 and SRP-dependent cotranslational protein targeting to membrane and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0010467 and gene expression and biological process this GO :0015935 and small ribosomal subunit and cellular component this GO :0016020 and membrane and cellular component this GO :0016032 and viral process and biological process this GO :0016070 and RNA metabolic process and biological process this GO :0016071 and mRNA metabolic process and biological process this GO :0019058 and viral life cycle and biological process this GO :0019083 and viral transcription and biological process this GO :0019899 and enzyme binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0022627 and cytosolic small ribosomal subunit and cellular component this GO :0030529 and ribonucleoprotein complex and cellular component this GO :0032587 and ruffle membrane and cellular component this GO :0044267 and cellular protein metabolic process and biological process this GO :0044822 and poly(A) RNA binding and molecular function this GO :0045738 and negative regulation of DNA repair and biological process this GO :0051018 and protein kinase A binding and molecular function this GO :0051059 and NF-kappaB binding and molecular function this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051536 and iron-sulfur cluster binding and molecular function this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071159 and NF-kappaB complex and cellular component this GO :0090305 and nucleic acid phosphodiester bond hydrolysis and biological process this GO :1902546 and positive regulation of DNA N-glycosylase activity and biological process this GO :2001235 and positive regulation of apoptotic signaling pathway and biological process, iron-sulfur cluster binding, nonsense-mediated decay and biological process this GO :0000737 and DNA catabolic process, nuclei, this GO :0000184 and nuclear-transcribed mRNA catabolic process, this GO :0003684: damaged DNA binding, this GO :0003684: damaged DNA binding and also this GO :0003723: RNA binding and also this GO :0003729: mRNA binding and also this GO :0003735: structural constituent of ribosome and also this GO :0003906: DNA-(apurinic or apyrimidinic site) lyase activity and also this GO :0004519: endonuclease activity and also this GO :0005515: protein binding and also this GO :0019899: enzyme binding and also this GO :0019901: protein kinase binding and also this GO :0044822: poly(A) RNA binding and also this GO :0051018: protein kinase A binding and also this GO :0051059: NF-kappaB binding and also this GO :0051536: iron-sulfur cluster binding, this GO :0003723: RNA binding, this GO :0003729: mRNA binding, this GO :0003735: structural constituent of ribosome, this GO :0003906: DNA-(apurinic or apyrimidinic site) lyase activity, this GO :0004519: endonuclease activity, this GO :0005515: protein binding, this GO :0019899: enzyme binding, this GO :0019901: protein kinase binding, this GO :0044822: poly(A) RNA binding, this GO :0051018: protein kinase A binding, this GO :0051059: NF-kappaB binding, this GO :0051536: iron-sulfur cluster binding, ribosomal protein S3 |
| Identity | 10420 |
| Gene | RPS3 |
| Long gene name | ribosomal protein S3 |
| Synonyms name | IMR-90 ribosomal protein S3 40S ribosomal protein S3 |
| Locus | 11q13, 4 |
| Discovery year | 1994-12-02 |
| Entrez gene record | 6188 |
| Pubmed identfication | 1712897 7789996 |
| RefSeq identity | NM_001005 |
| Classification | S ribosomal proteins |
| Havana BLAST/BLAT | OTTHUMG00000165448 |