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Anti-SDF1 (Polyclonal), ALEXA Fluor 594

Anti-SDF1 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideSDF1
SpecificityThis antibody reacts specifically with SDF1
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsSecreted
Antigen SourceKLH conjugated synthetic peptide derived from human SDF-1/CXCL12
Gene ID6387
Swiss ProtP48061
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis, Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase, Also binds to atypical chemokine receptor ACKR3, Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites, CXCR4 and ACKR3, Has several critical functions during embryonic development, Induces down-regulation and internalization of ACKR3 expressed in various cells, Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1, Plays a protective role after myocardial infarction, SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity, SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase, Stimulates migration of monocytes and T-lymphocytes through its receptors, a ligand for beta-2 integrins, and decreases monocyte adherence to surfaces coated with ICAM-1, but not neutrophils, monocytes, myelopoiesis in bone marrow and heart ventricular septum formation, required for B-cell lymphopoiesis, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1, Chemoattractant active on T-lymphocytes
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms SCYB12 SDF-1a SDF-1b PBSF TLSF-a TLSF-b TPAR1
Also known asSDF1 Polyclonal Antibody
Other nameAnti-SDF1 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetSDF1
Short nameAnti-SDF1 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-SDF1 (polyclonal)
Alternative techniquepolyclonals
Identity 10672
Gene CXCL12
Long gene name C-X-C motif chemokine ligand 12
Synonyms gene SDF1A SDF1B SDF1
Synonyms gene name stromal cell-derived factor 1 chemokine (C-X-C motif) ligand 12
Locus 10q11, 21
Discovery year 1994-11-30
GenBank acession L36033
Entrez gene record 6387
Pubmed identfication 7490086
RefSeq identity NM_000609
Classification Endogenous ligands Chemokine ligands
Havana BLAST/BLAT OTTHUMG00000018054

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