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Anti-Separase (Polyclonal), ALEXA Fluor 594

Anti-Separase (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideSeparase
SpecificityThis antibody reacts specifically with Separase
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human ESPL1
Gene ID9700
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information As the cellular division process continues, Cohesin plays an important role in cohering sister chromatids during the prophase through anaphase stages of mitosis, Each cell must receive one chromatid of every chromosome, It not only cleaves cohesin at the onset of anaphase but also cleaves itself, Separase activity is highly regulated, Should a human cell become an aneuploid (one too many or too few chromatids), Should the embryo survive, allowing the chromatids to separate and divide with the cell, during mitosis, it will most likely develop severe birth defects or later develop malignant cancers, making certain that genomic information is replicated accurately, promoting downregulation of separase after anaphase, separase destroys cohesin by means of cleavage, the embryo most likely will not survive, Separase is a cysteine protease that is essential for mitotic progression by separating sister chromatids
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms KIAA0165 ESP1 SEPA
Also known asSeparase Polyclonal Antibody
Other nameAnti-Separase Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetSeparase
Short nameAnti-Separase (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-Separase (polyclonal)
Alternative techniquepolyclonals
Identity 16856
Gene ESPL1
Long gene name extra spindle pole bodies like 1, separase
Synonyms gene name cerevisiae) , cerevisiae) extra spindle pole bodies homolog 1 (S, extra spindle poles like 1 (S
Synonyms name cysteine protease , separin separase separin
Locus 12q13, 13
Discovery year 2002-01-03
GenBank acession D79987
Entrez gene record 9700
Pubmed identfication 8724849 16258266
RefSeq identity NM_012291
Havana BLAST/BLAT OTTHUMG00000169674

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