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Anti-SH3KBP1 (Polyclonal), ALEXA Fluor 594

Anti-SH3KBP1 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideSH3KBP1
SpecificityThis antibody reacts specifically with SH3KBP1
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human SH3KBP1
Gene ID30011
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Alternate splicing results in multiple transcript variants, In the case of EGF receptor turnover, Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation, SH3KBP1 is involved in regulating diverse signal transduction pathways, The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases, a proline rich region and a C-terminal coiled-coil domain, characterized by containing three N-terminal Src homology domains, including EGFR and MET/hepatocyte growth factor receptor, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization, through a association with CBL and endophilins, SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms CIN85
Also known asSH3KBP1 Polyclonal Antibody
Other nameAnti-SH3KBP1 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetSH3KBP1
Short nameAnti-SH3KBP1 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-SH3-domain phosphorylation catalyst binding protein 1 (polyclonal)
Alternative techniquepolyclonals
Alternative to gene target BT, Cell surfaces, SH3 domain binding, SH3KBP1 and IDBG-49936 and ENSG00000147010 and 30011, Sh3kbp1 and IDBG-182475 and ENSMUSG00000040990 and 58194, this GO :0005515 and protein binding and molecular function this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0005925 and focal adhesion and cellular component this GO :0006897 and endocytosis and biological process this GO :0006915 and apoptotic process and biological process this GO :0007010 and cytoskeleton organization and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0008360 and regulation of cell shape and biological process this GO :0016301 and kinase activity and molecular function this GO :0016310 and phosphorylation and biological process this GO :0016477 and cell migration and biological process this GO :0017124 and SH3 domain binding and molecular function this GO :0030659 and cytoplasmic vesicle membrane and cellular component this GO :0042059 and negative regulation of epidermal growth factor receptor signaling pathway and biological process this GO :0043005 and neuron projection and cellular component this GO :0045202 and synapse and cellular component, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0016301: kinase activity and also this GO :0017124: SH3 domain binding, this GO :0016301: kinase activity, this GO :0017124: SH3 domain binding, 104277 and IDBG-638563 and ENSBTAG00000003727 and 510489, SH3-domain kinase binding protein 1
Identity 13867
Gene SH3KBP1
Long gene name SH3 domain containing kinase binding protein 1
Locus Xp22, 12
Discovery year 2000-12-14
GenBank acession AF230904
Entrez gene record 30011
Pubmed identfication 8889549 7566098
RefSeq identity NM_031892
Havana BLAST/BLAT OTTHUMG00000021227
Locus Specific Databases Mental Retardation database

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