Anti-SHC(Tyr349) (Polyclonal), ALEXA Fluor 594

Anti-SHC(Tyr349) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

Price 516

Size 100 microliters

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Type	Conjugated Primary Antibody
Conjugated with	594, ALEXA FLUOR®
Host organism	Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide	SHC Tyr349
Specificity	This antibody reacts specifically with SHC(Tyr349)
Modification	Phosphorylation
Modification site	Tyr349
Clonality	Polyclonal Antibody
Clone	Polyclonal Antibodies
Concentration	1ug per 1ul
Subcellular locations	N/A
Antigen Source	KLH conjugated synthetic phosphopeptide derived from human SHC around the phosphorylation site of Tyr349
Gene ID	6464
Swiss Prot	N/A
Applications	IF(IHC-P)
Applications with corresponding dilutions	IF(IHC-P)(1:50-200)
Cross reactive species	Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details	However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information	Adjacent to the SH2 region is a glycine and proline rich region, SHC proteins are involved in mitogenic signal transduction and act by coupling growth factor receptors to the RAS signaling pathway, The SHC gene encodes 2 widely expressed overlapping proteins of 46 and 52 kD, The protein encoded by the SHC1 gene is thought to act as an adaptor in many signal transduction pathways, These 2 proteins differ in their N terminals, both containing a C-terminal SH2 domain, The SHC gene encodes for a signaling and transforming protein containing Src homology 2 and 3 (SH2 and SH3) domains
Purification method	Purified by Protein A
Storage	50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission	590nm/617nm
Synonyms	p66 ShcA
Also known as	SHC(Tyr349) Polyclonal Antibody
Other name	Anti-SHC(Tyr349) Polyclonal
Advisory	For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
Properties	For facs or microscopy Alexa 1 conjugate
Conjugation	Alexa Fluor
Group	Polyclonals and antibodies
About	The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene target	SHC(Tyr349)
Short name	Anti-SHC(Tyr349) (Polyclonal) Fluor 594
Technique	Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different
Label	ALEXA
Alternative name	ALEXA Fluor 594, antibody to-SHC(Tyr349) (polyclonal)
Alternative technique	polyclonals
Identity	10840
Gene	SHC1
Long gene name	SHC adaptor protein 1
Synonyms gene	SHC
Synonyms gene name	SHC (Src homology 2 domain-containing) transforming protein 1
Locus	1q21, 3
Discovery year	1993-02-17
GenBank acession	U73377
Entrez gene record	6464
Pubmed identfication	1623525
RefSeq identity	NM_183001
Classification	SH2 domain containing
Havana BLAST/BLAT	OTTHUMG00000037295

Anti-SHC(Tyr349) (Polyclonal), ALEXA Fluor 594

Anti-SHC(Tyr349) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

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