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Anti-SLC12A6/KCC3 (Polyclonal), ALEXA Fluor 594

Anti-SLC12A6/KCC3 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideSLC12A6/KCC3
SpecificityThis antibody reacts specifically with SLC12A6/KCC3
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human SLC12A6/KCC3
Gene IDN/A
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Alterations of KCC2 expression in the inferior colliculus of rat brain may be related to seizure susceptibility, Conversely, In neurons, KCC2 expression is correlated with an inhibitory response to GABA, KCC2 expression is limited to neuronal tissues by a restrictive element similar to the neuronal-restrictive silencing factor, KCC3 is not suspected to play a major role in epilepsy, KCC3a and KCC3b, Nitric oxide (NO) donors activate KCCs, The two splice variants of KCC3, The ubiquitously expressed KCC1 contains 12 transmembrane domains with both cytoplasmic N and C terminal domains, are predominantly expressed in brain and kidney, brain, heart and kidney, lung, respectively, while KCC4 is expressed in muscle, while inhibitors of the cGMP pathway prevent NO donor activation, while the absence of KCC2 is necessary for an unusual excitatory response to GABA, The four isoforms of potassium/chloride co-transport channels (KCC) belong to a superfamily of cation-chloride co-transporters involved in cell volume maintenance
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Also known asSLC12A6/KCC3 Polyclonal Antibody
Other nameAnti-SLC12A6/KCC3 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetSLC12A6/KCC3
Short nameAnti-SLC12A6/KCC3 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-SLC12A6/KCC3 (polyclonal)
Alternative techniquepolyclonals
Identity 10914
Gene SLC12A6
Long gene name solute carrier family 12 member 6
Synonyms gene KCC3 ACCPN
Synonyms gene name agenesis of corpus callosum and peripheral neuropathy (Andermann syndrome) solute carrier family 12 (potassium/chloride transporter), member 6
Locus 15q14
Discovery year 1999-05-25
GenBank acession AF108831
Entrez gene record 9990
Pubmed identfication 10187864 10347194
RefSeq identity NM_005135
Classification Solute carriers
Havana BLAST/BLAT OTTHUMG00000129441
Locus Specific Databases Inherited Peripheral Neuropathies Mutation Database LRG_270

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