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Anti-SNAIL Antibody

Anti-SNAIL Antibody size: 0.4 ml 406

Supplier NJS POLY
Price 406
Size 0.4 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormPurified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenAnti-SNAIL
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, WB, IHC
Recommended dilutionsIHC (Paraffin): 1:10-1:50, Western blot: 1:1000
NotesTitration of the anti-SNAIL antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis anti-SNAIL antibodyis to be used only for research purposes and not for diagnostics
Uniprot #O95863
PurityPurified
Description At least two variants of a similar processed pseudogene have been found on chromosome 2, However, Other studies show that mutation of specific ZFs contribute to a decrease in SNAI1 E-cadherin repression, SNAI1 zinc-fingers (ZF) binds to E-box, The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, This process allows for the formation of the mesodermal layer in the developing embryo, Though SNAI1 is shown to repress expression of E-cadherin in epithelial cells, [Wiki], an E-cadherin promoter region, and is also thought to be critical for mesoderm formation in the developing embryo, and represses the expression of the adhesion molecule, commonly known as Snail, is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm, studies have shown homozygous mutant embryos are still able to form a mesodermal layer, the mesodermal layer present shows characteristics of epithelial cells and not mesenchymal cells (the mutant mesoderm cells exhibited a polarized state), which induces the tightly bound epithelial cells to break loose from each other and migrate into the developing embryo to become mesenchymal cells, The Drosophila embryonic protein SNAI1
ImmunogenA portion of amino acids 9-39 from the human protein was used as the immunogen for this anti-SNAIL antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the anti-SNAIL antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetSNAIL
Short nameAnti-SNAIL Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameantibody to-SNAIL (Antibody to)
Alternative techniqueantibodies
Identity 11128
Gene SNAI1
Long gene name snail family transcriptional repressor 1
Synonyms gene name snail 1 (drosophila homolog), zinc finger protein snail homolog 1 (Drosophila) snail family zinc finger 1
Synonyms SNA SLUGH2 SNAH SNAIL1 SNAIL
Locus 20q13, 13
Discovery year 1998-07-03
GenBank acession AF125377
Entrez gene record 6615
Pubmed identfication 10585766
Classification Zinc fingers C2H2-type SNAG transcriptional repressors
Havana BLAST/BLAT OTTHUMG00000033048

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