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Anti-SOCS5 (Polyclonal), ALEXA Fluor 594

Anti-SOCS5 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideSOCS5
SpecificityThis antibody reacts specifically with SOCS5
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human SOCS5
Gene IDN/A
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information During Th1 differentiation a reduction in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5, SOCS2, SOCS3, SOCS4, SOCS5, SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of receptor tyrosine phosphorylation, SOCS6, SOCS7, Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL4-mediated Th2 development, The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction, Therefore, This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition of IL4-mediated signal transducer and activator of transcription-6 activation, Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, a central SH2 domain, and CIS, and a C-terminal motif called the SOCS box, and once produced, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance, the various members of the SOCS family appear to inhibit signaling in different ways, The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms KIAA0671 SOCS-5 CIS6 CISH6 Cish5
Also known asSOCS5 Polyclonal Antibody
Other nameAnti-SOCS5 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetSOCS5
Short nameAnti-SOCS5 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-suppressor on cytokine signaling 5 (polyclonal)
Alternative techniquepolyclonals
Alternative to gene target BT, CIS6 and Cish5 and CISH6 and SOCS-5, SOCS5 and IDBG-50628 and ENSG00000171150 and 9655, Socs5 and IDBG-201346 and ENSMUSG00000037104 and 56468, multiple, receptor tyrosine kinase binding, this GO :0005154 and epidermal growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007175 and negative regulation of epidermal growth factor-activated receptor activity and biological process this GO :0007259 and JAK-STAT cascade and biological process this GO :0009968 and negative regulation of signal transduction and biological process this GO :0016049 and cell growth and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0030971 and receptor tyrosine kinase binding and molecular function this GO :0032436 and positive regulation of proteasomal ubiquitin-dependent protein catabolic process and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0040008 and regulation of growth and biological process this GO :0045087 and innate immune response and biological process this GO :0045627 and positive regulation of T-helper 1 cell differentiation and biological process this GO :0045629 and negative regulation of T-helper 2 cell differentiation and biological process, this GO :0005154: epidermal growth factor receptor binding, this GO :0005154: epidermal growth factor receptor binding and also this GO :0005515: protein binding and also this GO :0030971: receptor tyrosine kinase binding, this GO :0005515: protein binding, this GO :0030971: receptor tyrosine kinase binding, 58314 and IDBG-633338 and ENSBTAG00000008987 and 514773, suppressor of cytokine signaling 5
Identity 16852
Gene SOCS5
Long gene name suppressor of cytokine signaling 5
Locus 2p21
Discovery year 2002-11-13
GenBank acession AB014571
Pubmed identfication 9734811 11230166
Classification Suppressors of cytokine signaling SH2 domain containing
Havana BLAST/BLAT OTTHUMG00000128852

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