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Anti-SPG7/Paraplegin (Polyclonal), ALEXA Fluor 594

Anti-SPG7/Paraplegin (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideSPG7/Paraplegin
SpecificityThis antibody reacts specifically with SPG7/Paraplegin
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human Paraplegin
Gene IDN/A
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Defects in the gene encoding Paraplegin are the cause of spastic paraplegia type 7 (SPG7), HSPs are degenerative spinal cord disorders that are characterized by muscle spasms, Localized to the mitochrondrial membrane and expressed throughout the body, Paraplegin is a multi-pass membrane protein that is thought to be involved in signal transduction and chaperone-like activities in the mitochrondria, Recent studies suggest that SPG7 may be a mitochondrial-based disease, These mitochondrial dysfunctions lead to axonal degeneration and impaired axonal transport, a form of autosomal recessive hereditary spastic paraplegia (AR-HSP), as mutations in the Paraplegin gene lead to ragged-red fibers, in some cases, incontinence, oxidase-negative fibers and intense succinate dehydrogenase-stained areas of the mitochrondria, stiffness in the legs and, thus causing the neurodegeneration seen in HSPs, Paraplegin is a 795 amino acid metalloprotease that is a member of the AAA protein family
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms CAR SPG5C
Also known asSPG7/Paraplegin Polyclonal Antibody
Other nameAnti-SPG7/Paraplegin Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetSPG7/Paraplegin
Short nameAnti-SPG7/Paraplegin (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-SPG7/Paraplegin (polyclonal)
Alternative techniquepolyclonals
Identity 11237
Gene SPG7
Long gene name SPG7, paraplegin matrix AAA peptidase subunit
Synonyms gene CMAR
Synonyms gene name cell matrix adhesion regulator spastic paraplegia 7 (pure and complicated autosomal recessive)
Synonyms name paraplegin
Locus 16q24, 3
Discovery year 1998-06-25
GenBank acession Y16610
Entrez gene record 6687
Pubmed identfication 9635427 9634528
RefSeq identity NM_003119
Classification AAA ATPases
Havana BLAST/BLAT OTTHUMG00000138046
Locus Specific Databases ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

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