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Anti-SPR/Sepiapterin reductase, ALEXA Fluor 594

Anti-SPR/Sepiapterin reductase, ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideSPR/Sepiapterin reductase
SpecificityThis antibody reacts specifically with SPR/Sepiapterin reductase
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human Sepiapterin reductase
Gene IDN/A
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information BH4 is an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, In addition, In addition, Mutations in the gene encoding SPR can cause sepiapterin reductase deficiency, SPR functions as an NADH-dependent aldo-keto reductase and specifically catalyzes the reduction of pteridine derivatives, SPR mRNA expression is increased in the brain of Parkinsonâ, SPR plays an important role in tetrahydrobiopterin (BH4) biosynthesis, Sepiapterin reductase deficiency interferes with BH4 synthesis, a monoamine neurotransmitter deficiency without hyperphenylalaninemia, also known as sepiapterin reductase, catalyzing the final reduction step of the synthesis pathway, is a homodimeric cytoplasmic protein that belongs to the sepiapterin reductase family, resulting in DOPA-responsive dystonia and a variety of other human diseases, suggesting that SPR may play a role in PD, tyrosine and phenylalanine) and is required for proper dopamine synthesis, &euro, &trade, SPR, s Disease (PD) patients
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms SDR38C1
Also known asSPR/Sepiapterin reductase Antibody
Other nameAnti-SPR/Sepiapterin reductase
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetSPR/Sepiapterin reductase
Short name Fluor 594, Anti-SPR/Sepiapterin reductase
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-SPR/Sepiapterin reductase
Identity 11257
Gene SPR
Long gene name sepiapterin reductase (7, 8-dihydrobiopterin:NADP+ oxidoreductase)
Synonyms name member 1 , short chain dehydrogenase/reductase family 38C
Locus 2p13, 2
Discovery year 1991-12-05
Entrez gene record 6697
Pubmed identfication 1883349 19027726
Classification Short chain dehydrogenase/reductase superfamily
Havana BLAST/BLAT OTTHUMG00000129777
Locus Specific Databases BIOMBD

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