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Anti-SYT1(Ser309) (Polyclonal), ALEXA Fluor 594
Anti-SYT1(Ser309) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516
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BIOSS POLYCLONAL ANTIBODIES
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516
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100 microliters
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| Type | Conjugated Primary Antibody |
| Conjugated with | 594, ALEXA FLUOR® |
| Host organism | Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide | SYT1 Ser309 |
| Specificity | This antibody reacts specifically with SYT1(Ser309) |
| Modification | Phosphorylation |
| Modification site | Ser309 |
| Clonality | Polyclonal Antibody |
| Clone | Polyclonal Antibodies |
| Concentration | 1ug per 1ul |
| Subcellular locations | N/A |
| Antigen Source | KLH conjugated synthetic phosphopeptide derived from human SYT1 around the phosphorylation site of Ser309 |
| Gene ID | 6857 |
| Swiss Prot | N/A |
| Applications | IF(IHC-P) |
| Applications with corresponding dilutions | IF(IHC-P)(1:50-200) |
| Cross reactive species | Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details | However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information | A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported, Calcium binding to synaptotagmin participates in triggering neurotransmitter release at the synapse, It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone, It can bind to at least three additional proteins in a Ca(2+)-independent manner, Synaptotagmin may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse, The first C2 domain mediates Ca(2+)-dependent phospholipid binding, The second C2 domain mediates interaction with Stonin 2, syntaxin and AP2, these are neurexins, The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis |
| Purification method | Purified by Protein A |
| Storage | 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission | 590nm/617nm |
| Synonyms | P65 |
| Also known as | SYT1(Ser309) Polyclonal Antibody |
| Other name | Anti-SYT1(Ser309) Polyclonal |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties | For facs or microscopy Alexa 1 conjugate |
| Conjugation | Alexa Fluor |
| Group | Polyclonals and antibodies |
| About | The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target | SYT1(Ser309) |
| Short name | Anti-SYT1(Ser309) (Polyclonal) Fluor 594 |
| Technique | Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label | ALEXA |
| Alternative name | ALEXA Fluor 594, antibody to-synaptotagmin I(Ser309) (polyclonal) |
| Alternative technique | polyclonals |
| Alternative to gene target | Cell surfaces, P65 and SVP65 and SYT, SYT1 and IDBG-49321 and ENSG00000067715 and 6857, SYT1 and IDBG-630189 and ENSBTAG00000034693 and 101909273, Syt1 and IDBG-189557 and ENSMUSG00000035864 and 20979, phosphatidylinositol-4, this GO :0000149 and SNARE binding and molecular function this GO :0001786 and phosphatidylserine binding and molecular function this GO :0005215 and transporter activity and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005513 and detection of calcium ion and biological process this GO :0005515 and protein binding and molecular function this GO :0005516 and calmodulin binding and molecular function this GO :0005543 and phospholipid binding and molecular function this GO :0005544 and calcium-dependent phospholipid binding and molecular function this GO :0005545 and 1-phosphatidylinositol binding and molecular function this GO :0005546 and phosphatidylinositol-4, this GO :0000149: SNARE binding, this GO :0000149: SNARE binding and also this GO :0001786: phosphatidylserine binding and also this GO :0005215: transporter activity and also this GO :0005509: calcium ion binding and also this GO :0005515: protein binding and also this GO :0005516: calmodulin binding and also this GO :0005543: phospholipid binding and also this GO :0005544: calcium-dependent phospholipid binding and also this GO :0005545: 1-phosphatidylinositol binding and also this GO :0005546: phosphatidylinositol-4, this GO :0001786: phosphatidylserine binding, this GO :0005215: transporter activity, this GO :0005509: calcium ion binding, this GO :0005515: protein binding, this GO :0005516: calmodulin binding, this GO :0005543: phospholipid binding, this GO :0005544: calcium-dependent phospholipid binding, this GO :0005545: 1-phosphatidylinositol binding, this GO :0005546: phosphatidylinositol-4, this GO :0008022: protein C-terminus binding, this GO :0017075: syntaxin-1 binding, this GO :0019905: syntaxin binding, this GO :0030276: clathrin binding, this GO :0042802: identical protein binding, this GO :0048306: calcium-dependent protein binding, this GO :0050750: low-density lipoprotein particle receptor binding, 281511, 5-bisphosphate binding, 5-bisphosphate binding and also this GO :0008022: protein C-terminus binding and also this GO :0017075: syntaxin-1 binding and also this GO :0019905: syntaxin binding and also this GO :0030276: clathrin binding and also this GO :0042802: identical protein binding and also this GO :0048306: calcium-dependent protein binding and also this GO :0050750: low-density lipoprotein particle receptor binding, 5-bisphosphate binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006810 and transport and biological process this GO :0007268 and synaptic transmission and biological process this GO :0007269 and neurotransmitter secretion and biological process this GO :0008021 and synaptic vesicle and cellular component this GO :0008022 and protein C-terminus binding and molecular function this GO :0014047 and glutamate secretion and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016079 and synaptic vesicle exocytosis and biological process this GO :0017075 and syntaxin-1 binding and molecular function this GO :0017157 and regulation of exocytosis and biological process this GO :0017158 and regulation of calcium ion-dependent exocytosis and biological process this GO :0019905 and syntaxin binding and molecular function this GO :0030054 and cell junction and cellular component this GO :0030141 and secretory granule and cellular component this GO :0030276 and clathrin binding and molecular function this GO :0030666 and endocytic vesicle membrane and cellular component this GO :0030672 and synaptic vesicle membrane and cellular component this GO :0031045 and dense core granule and cellular component this GO :0031201 and SNARE complex and cellular component this GO :0031340 and positive regulation of vesicle fusion and biological process this GO :0042584 and chromaffin granule membrane and cellular component this GO :0042734 and presynaptic membrane and cellular component this GO :0042802 and identical protein binding and molecular function this GO :0043005 and neuron projection and cellular component this GO :0043229 and intracellular organelle and cellular component this GO :0045956 and positive regulation of calcium ion-dependent exocytosis and biological process this GO :0048278 and vesicle docking and biological process this GO :0048306 and calcium-dependent protein binding and molecular function this GO :0050750 and low-density lipoprotein particle receptor binding and molecular function this GO :0051260 and protein homooli this GO merization and biological process this GO :0051592 and response to calcium ion and biological process this GO :0060076 and excitatory synapse and cellular component this GO :0060201 and clathrin-sculpted acetylcholine transport vesicle membrane and cellular component this GO :0060203 and clathrin-sculpted glutamate transport vesicle membrane and cellular component this GO :0061202 and clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane and cellular component this GO :0070083 and clathrin-sculpted monoamine transport vesicle membrane and cellular component, synaptotagmin I |
| Identity | 11509 |
| Gene | SYT1 |
| Long gene name | synaptotagmin 1 |
| Synonyms gene | SYT SVP65 |
| Synonyms gene name | synaptotagmin I |
| Locus | 12q21, 2 |
| Discovery year | 1990-03-14 |
| Entrez gene record | 6857 |
| Pubmed identfication | 1840599 |
| RefSeq identity | NM_005639 |
| Classification | Synaptotagmins |
| Havana BLAST/BLAT | OTTHUMG00000134326 |