Name : Anti-TLR7 (Polyclonal), ALEXA Fluor 594
Supplier : BIOSS POLYCLONAL ANTIBODIES
Price :489
SKU : GEN4678490759
| Type | Conjugated Primary Antibody |
| Conjugated with | 594, ALEXA FLUOR® |
| Host organism | Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide | TLR7 |
| Specificity | This antibody reacts specifically with TLR7 |
| Modification | No modification has been applied to this antibody |
| Modification site | None |
| Clonality | Polyclonal Antibody |
| Clone | Polyclonal Antibodies |
| Concentration | 1ug per 1ul |
| Subcellular locations | Intracellular |
| Antigen Source | KLH conjugated synthetic peptide derived from human TLR7 |
| Gene ID | 51284 |
| Swiss Prot | Q9NYK1 |
| Applications | IF(IHC-P) |
| Applications with corresponding dilutions | IF(IHC-P)(1:50-200) |
| Cross reactive species | Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details | However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information | Acts via MYD88 and TRAF6, TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA, TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms, cytokine secretion and the inflammatory response (By similarity), leading to NF-kappa-B activation, Key component of innate and adaptive immunity |
| Purification method | Purified by Protein A |
| Storage | 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission | 590nm/617nm |
| Also known as | TLR7 Polyclonal Antibody |
| Other name | Anti-TLR7 Polyclonal |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties | For facs or microscopy Alexa 1 conjugate |
| Conjugation | Alexa Fluor |
| Group | Polyclonals and antibodies |
| About | The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target | TLR7 |
| Short name | Anti-TLR7 (Polyclonal) Fluor 594 |
| Technique | Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different  |
| Label | ALEXA |
| Alternative name | ALEXA Fluor 594, antibody to-toll-like receptor 7 (polyclonal) |
| Alternative technique | polyclonals |
| Alternative to gene target | Plasma membranes, TLR7 and IDBG-44230 and ENSG00000196664 and 51284, TLR7 and IDBG-639302 and ENSBTAG00000022161 and 493686, Tlr7 and IDBG-185532 and ENSMUSG00000044583 and 170743, siRNA binding, this GO :0000139 and this GO lgi membrane and cellular component this GO :0001774 and microglial cell activation and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0003725 and double-stranded RNA binding and molecular function this GO :0003727 and single-stranded RNA binding and molecular function this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005764 and lysosome and cellular component this GO :0005768 and endosome and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006954 and inflammatory response and biological process this GO :0007165 and signal transduction and biological process this GO :0007252 and I-kappaB phosphorylation and biological process this GO :0008144 and drug binding and molecular function this GO :0010008 and endosome membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0032009 and early pha this GO some and cellular component this GO :0032722 and positive regulation of chemokine production and biological process this GO :0032755 and positive regulation of interleukin-6 production and biological process this GO :0032757 and positive regulation of interleukin-8 production and biological process this GO :0034154 and toll-like receptor 7 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0035197 and siRNA binding and molecular function this GO :0036020 and endolysosome membrane and cellular component this GO :0042346 and positive regulation of NF-kappaB import into nucleus and biological process this GO :0043235 and receptor complex and cellular component this GO :0045078 and positive regulation of interferon-gamma biosynthetic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045356 and positive regulation of interferon-alpha biosynthetic process and biological process this GO :0045359 and positive regulation of interferon-beta biosynthetic process and biological process this GO :0045416 and positive regulation of interleukin-8 biosynthetic process and biological process this GO :0050729 and positive regulation of inflammatory response and biological process this GO :0051607 and defense response to virus and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process, this GO :0003725: double-stranded RNA binding, this GO :0003725: double-stranded RNA binding and also this GO :0003727: single-stranded RNA binding and also this GO :0004888: transmembrane signaling receptor activity and also this GO :0005515: protein binding and also this GO :0008144: drug binding and also this GO :0035197: siRNA binding, this GO :0003727: single-stranded RNA binding, this GO :0004888: transmembrane signaling receptor activity, this GO :0005515: protein binding, this GO :0008144: drug binding, this GO :0035197: siRNA binding, toll-like receptor 7 |
| Identity | 15631 |
| Gene | TLR7 |
| Long gene name | toll like receptor 7 |
| Synonyms gene name | toll-like receptor 7 |
| Locus | Xp22, 2 |
| Discovery year | 2001-04-27 |
| GenBank acession | AF240467 |
| Entrez gene record | 51284 |
| Pubmed identfication | 11022119 |
| RefSeq identity | NM_016562 |
| Classification | Toll like receptors |
| Havana BLAST/BLAT | OTTHUMG00000021137 |
| Locus Specific Databases | Mental Retardation database |