Anti-TSC1(Ser505) (Polyclonal), ALEXA Fluor 594

Anti-TSC1(Ser505) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

Price 516

Size 100 microliters

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Type	Conjugated Primary Antibody
Conjugated with	594, ALEXA FLUOR®
Host organism	Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide	TSC1 Ser505
Specificity	This antibody reacts specifically with TSC1(Ser505)
Modification	Phosphorylation
Modification site	Ser505
Clonality	Polyclonal Antibody
Clone	Polyclonal Antibodies
Concentration	1ug per 1ul
Subcellular locations	N/A
Antigen Source	KLH conjugated synthetic phosphopeptide derived from human TSC1 around the phosphorylation site of Ser505 [FD(p-S)PF]
Gene ID	7248
Swiss Prot	N/A
Applications	IF(IHC-P)
Applications with corresponding dilutions	IF(IHC-P)(1:50-200)
Cross reactive species	Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details	However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information	Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, TSC1 interacts with tuberin m(TSC2), The Hamartin/Tuberin complex has been shown to inhibit mTor, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1, or TSC1, suggesting a role for TSC proteins in modulation of cell adhesion and morphology, which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins, Hamartin
Purification method	Purified by Protein A
Storage	50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission	590nm/617nm
Synonyms	KIAA0243 LAM hamartin
Also known as	TSC1(Ser505) Polyclonal Antibody
Other name	Anti-TSC1(Ser505) Polyclonal
Advisory	For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
Properties	For facs or microscopy Alexa 1 conjugate
Conjugation	Alexa Fluor
Group	Polyclonals and antibodies
About	The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene target	TSC1(Ser505)
Short name	Anti-TSC1(Ser505) (Polyclonal) Fluor 594
Technique	Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different
Label	ALEXA
Alternative name	ALEXA Fluor 594, antibody to-TSC1(Ser505) (polyclonal)
Alternative technique	polyclonals
Identity	12362
Gene	TSC1
Long gene name	tuberous sclerosis 1
Synonyms gene	TSC
Locus	9q34
Discovery year	1986-01-01
GenBank acession	AF013168
Pubmed identfication	9242607 10806479
Havana BLAST/BLAT	OTTHUMG00000020844
Locus Specific Databases	TSC Mutation Database Tuberous sclerosis database LRG_486

Anti-TSC1(Ser505) (Polyclonal), ALEXA Fluor 594

Anti-TSC1(Ser505) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

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