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Anti-Twinkle/ATXN8 (Polyclonal), ALEXA Fluor 594

Anti-Twinkle/ATXN8 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideTwinkle/ATXN8
SpecificityThis antibody reacts specifically with Twinkle/ATXN8
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic peptide derived from human Twinkle/ATXN8
Gene IDN/A
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Colocalized with mtDNA (mitochondrial DNA) in mitochondrial nucleoids, Defects in the gene encoding Twinkle are the cause of two conditions: progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant 3 (PEOA3) and sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), PEOA3, PEOA3 is characterized by ptosis and weak muscles, SANDO or TWINL, Twinkle is expressed at high levels in testis, Twinkle is important in the metabolism and maintenance of mtDNA, also known as PEO1 (Progressive external ophthalmoplegia 1 protein), dysarthria and sensory ataxic neuropathies, is a mitochondrial protein that functions as a 5â, nucleotide-dependent DNA helicase, pancreas and skeletal muscle and exists as three isoforms due to alternative splicing events, playing a crucial role in the regulation of mtDNA copy numbers, while SANDO is characterized by ophthalmoparesis, &euro, &euro, &trade, &trade, -3â, Twinkle
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Also known asTwinkle/ATXN8 Polyclonal Antibody
Other nameAnti-Twinkle/ATXN8 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetTwinkle/ATXN8
Short nameAnti-Twinkle/ATXN8 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-Twinkle/ATXN8 (polyclonal)
Alternative techniquepolyclonals
Identity 32925
Gene ATXN8
Long gene name ataxin 8
Locus 13q21, 33
Discovery year 2006-07-18
GenBank acession DQ641254
Entrez gene record 724066
Pubmed identfication 16804541
Classification Ataxins

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