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Anti-Unc5a/UNC5H1 (Polyclonal), ALEXA Fluor 594

Anti-Unc5a/UNC5H1 (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideUnc5a/UNC5H1
SpecificityThis antibody reacts specifically with Unc5a/UNC5H1
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsExtracellular
Antigen SourceKLH conjugated synthetic peptide derived from human Unc5a
Gene IDN/A
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Additionally, In the absence of netrin-1, The expression of UNC5H receptors is downregulated in multiple carcinomas, This activity is blocked by the binding of netrin-1, Three isoforms of UNC5H1 exist due to alternative splicing events, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, UNC5H1, also known as UNC5HA (unc-5 homolog A), breast, but mutation of these receptors provides a potential mechanism for tumorigenicity, including colorectal, is a member of the UNC5H family of proteins and is localized to the cell membrane, lung and kidney cancers, ovary, stomach, uterus, when cleaved by a caspase to produce an intracellular fragment containing a death domain, The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells, UNC5H receptors induce apoptosis
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms KIAA1976 UNC5H1
Also known asUnc5a/UNC5H1 Polyclonal Antibody
Other nameAnti-Unc5a/UNC5H1 Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetUnc5a/UNC5H1
Short nameAnti-Unc5a/UNC5H1 (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, elegans)/UNC5H1 (polyclonal), antibody to-unc-5 homolog A (C
Alternative techniquepolyclonals
Identity 12567
Gene UNC5A
Long gene name unc-5 netrin receptor A
Synonyms gene name elegans) , unc5 (C, elegans homolog) a unc-5 homolog A (C
Locus 5q35, 2
Discovery year 1998-12-09
GenBank acession AB075856
Entrez gene record 90249
Pubmed identfication 12655055 20372800
RefSeq identity XM_030300
Classification I-set domain containing
Havana BLAST/BLAT OTTHUMG00000163225

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