Filters

Anti-WNK1(Thr60) (Polyclonal), ALEXA Fluor 594

Anti-WNK1(Thr60) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 516
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideWNK1 Thr60
SpecificityThis antibody reacts specifically with WNK1(Thr60)
ModificationPhosphorylation
Modification siteThr60
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locationsN/A
Antigen SourceKLH conjugated synthetic phosphopeptide derived from human WNK1 around the phosphorylation site of Thr60
Gene ID7465
Swiss ProtN/A
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information SLC12A3, WNK1 is widely expressed, WNK1 may also play a role in actin cytoskeletal reorganization, WNK4 regulates the activity of the thiazide sensitive Na/Cl cotransporter, an autosomal dominant disease characterized by severe hypertension, and sensitivity to thiazide diuretics which may result from a chloride shunt in the renal distal nephron, by phosphorylation, heart, hyperkalemia, kidney and skeletal muscle, potentially by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1, with highest levels observed in the testis, Defects in WNK1 are a cause of pseudohypoaldosteronism type II (PHAII), WNK1 controls sodium and chloride ion transport by inhibiting the activity of WNK4, WNK1 has 4 isoforms produced by alternative splicing
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms HSAN2 PPP1R167
Also known asWNK1(Thr60) Polyclonal Antibody
Other nameAnti-WNK1(Thr60) Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetWNK1(Thr60)
Short nameAnti-WNK1(Thr60) (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, antibody to-WNK lysine deficient protein kinase 1(Thr60) (polyclonal)
Alternative techniquepolyclonals
Alternative to gene target Cytoplasm, WNK1 and IDBG-11521 and ENSG00000060237 and 65125, WNK1 and IDBG-641017 and ENSBTAG00000005221 and 506433, Wnk1 and IDBG-183036 and ENSMUSG00000045962 and 232341, this GO :0003084 and positive regulation of systemic arterial blood pressure and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004860 and protein kinase inhibitor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0006811 and ion transport and biological process this GO :0010923 and negative regulation of phosphatase activity and biological process this GO :0016772 and transferase activity, this GO :0004672: protein kinase activity, this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0004860: protein kinase inhibitor activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016772: transferase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0004860: protein kinase inhibitor activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016772: transferase activity, this GO :0019869: chloride channel inhibitor activity, this GO :0019902: phosphatase binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019869: chloride channel inhibitor activity and also this GO :0019902: phosphatase binding, transferring phosphorus-containing groups and molecular function this GO :0018107 and peptidyl-threonine phosphorylation and biological process this GO :0019869 and chloride channel inhibitor activity and molecular function this GO :0019902 and phosphatase binding and molecular function this GO :0035556 and intracellular signal transduction and biological process this GO :0048666 and neuron development and biological process this GO :0050794 and regulation of cellular process and biological process this GO :0090188 and negative regulation of pancreatic juice secretion and biological process, WNK lysine deficient protein kinase 1
Identity 14540
Gene WNK1
Long gene name WNK lysine deficient protein kinase 1
Synonyms gene PRKWNK1 HSN2
Synonyms gene name lysine deficient 1 hereditary sensory neuropathy, protein kinase, type II
Synonyms name protein phosphatase 1, regulatory subunit 167
Locus 12p13, 33
Discovery year 2001-02-06
GenBank acession AJ296290
Entrez gene record 65125
RefSeq identity NM_018979
Classification Minor histocompatibility antigens Protein phosphatase 1 regulatory subunits
Havana BLAST/BLAT OTTHUMG00000090321
Locus Specific Databases Inherited Peripheral Neuropathies Mutation Database LRG_247

Similar products

Subscribe to our Newsletter