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Anti-XPC (Polyclonal), ALEXA Fluor 594

Anti-XPC (Polyclonal), ALEXA Fluor 594 size: 100 microliters 489

Supplier BIOSS POLYCLONAL ANTIBODIES
Price 489
Size 100 microliters
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
TypeConjugated Primary Antibody
Conjugated with 594, ALEXA FLUOR®
Host organismRabbit (Oryctolagus cuniculus)
Target Protein/PeptideXPC
SpecificityThis antibody reacts specifically with XPC
ModificationNo modification has been applied to this antibody
Modification siteNone
ClonalityPolyclonal Antibody
ClonePolyclonal Antibodies
Concentration1ug per 1ul
Subcellular locations Nucleus, Cytoplasm
Antigen SourceKLH conjugated synthetic peptide derived from human Xeroderma pigmentosum group C
Gene ID7508
Swiss ProtQ01831
ApplicationsIF(IHC-P)
Applications with corresponding dilutionsIF(IHC-P)(1:50-200)
Cross reactive species Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation, Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides, Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A, In vitro, Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair, RPA and the TFIIH complex, The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, The orientation of XPC complex binding appears to be crucial for inducing a productive NER, This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity, XPA, XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery, is part of the pre-incision (or initial recognition) complex, it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts, mismatched bubbles or single-stranded overhangs, the XPC:RAD23B dimer is sufficient to initiate NER, Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex
Purification methodPurified by Protein A
Storage 50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission590nm/617nm
Synonyms XPCC RAD4
Also known asXPC Polyclonal Antibody
Other nameAnti-XPC Polyclonal
Advisory For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
PropertiesFor facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
GroupPolyclonals and antibodies
About The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene targetXPC
Short nameAnti-XPC (Polyclonal) Fluor 594
Technique Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different 
LabelALEXA
Alternative name ALEXA Fluor 594, complementation group C (polyclonal), antibody to-xeroderma pigmentosum
Alternative techniquepolyclonals
Alternative to gene target DNA damage recognition and biological process this GO :0000718 and nucleotide-excision repair, DNA damage removal and biological process this GO :0003677 and DNA binding and molecular function this GO :0003684 and damaged DNA binding and molecular function this GO :0003697 and single-stranded DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006281 and DNA repair and biological process this GO :0006289 and nucleotide-excision repair and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0010224 and response to UV-B and biological process this GO :0031573 and intra-S DNA damage checkpoint and biological process this GO :0042493 and response to drug and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071942 and XPC complex and cellular component this GO :1901990 and regulation of mitotic cell cycle phase transition and biological process, XPC and IDBG-19992 and ENSG00000154767 and 7508, XPC and IDBG-646437 and ENSBTAG00000007362 and 524274, Xpc and IDBG-170258 and ENSMUSG00000030094 and 22591, complementation group C, nuclei, p125 and RAD4 and XP3 and XPCC, protein binding, this GO :0000404 and heteroduplex DNA loop binding and molecular function this GO :0000405 and bubble DNA binding and molecular function this GO :0000715 and nucleotide-excision repair, this GO :0000404: heteroduplex DNA loop binding, this GO :0000404: heteroduplex DNA loop binding and also this GO :0000405: bubble DNA binding and also this GO :0003677: DNA binding and also this GO :0003684: damaged DNA binding and also this GO :0003697: single-stranded DNA binding and also this GO :0005515: protein binding, this GO :0000405: bubble DNA binding, this GO :0003677: DNA binding, this GO :0003684: damaged DNA binding, this GO :0003697: single-stranded DNA binding, this GO :0005515: protein binding, xeroderma pigmentosum
Identity 12816
Gene XPC
Long gene name DNA damage recognition and repair factor , XPC complex subunit
Synonyms gene name complementation group C , xeroderma pigmentosum
Synonyms name xeroderma pigmentosum group C protein
Locus 3p25, 1
Discovery year 1992-10-05
Entrez gene record 7508
Pubmed identfication 1522891
RefSeq identity NM_004628
Classification Xeroderma pigmentosum complementation groups
Havana BLAST/BLAT OTTHUMG00000155526
Locus Specific Databases LRG_472

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