Anti-YES1 (Tyr426) (Polyclonal), ALEXA Fluor 594

Anti-YES1 (Tyr426) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

Price 516

Size 100 microliters

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Type	Conjugated Primary Antibody
Conjugated with	594, ALEXA FLUOR®
Host organism	Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide	YES1 Tyr426
Specificity	Src(Tyr418), and Lyn (Tyr397) if phosphorylated at this site due to homology, this antibody will react with the related proteins LCK(Tyr394), Due to the highly conserved nature of this protein, YES1 (Tyr426)
Modification	Phosphorylation
Modification site	Tyr426
Clonality	Polyclonal Antibody
Clone	Polyclonal Antibodies
Concentration	1ug per 1ul
Subcellular locations	Cytoplasm
Antigen Source	KLH conjugated synthetic phosphopeptide derived from human YES1 around the phosphorylation site of Tyr426
Gene ID	7525
Swiss Prot	P07947
Applications	IF(IHC-P)
Applications with corresponding dilutions	IF(IHC-P)(1:50-200)
Cross reactive species	Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens)
Cross Reactive Species details	However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species
Background information	Also involved in G2/M progression and cytokinesis, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, PDGFR, Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration, Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts, Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase, Stimulation by receptor tyrosine kinases (RTKs) including EGRF, Upon EGFR activation, Upon T-cell stimulation by CXCL12, and activation and phosphorylation of downstream substrates, and differentiation, apoptosis, cell-cell adhesion, cytoskeleton remodeling, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly, Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival
Purification method	Purified by Protein A
Storage	50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA
Excitation emission	590nm/617nm
Synonyms	Yes c-yes HsT441
Also known as	YES1 (Tyr426) Polyclonal Antibody
Other name	Anti-YES1 (Tyr426) Polyclonal
Advisory	For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody
Properties	For facs or microscopy Alexa 1 conjugate
Conjugation	Alexa Fluor
Group	Polyclonals and antibodies
About	The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot
Gene target	YES1 (Tyr426)
Short name	Anti-YES1 (Tyr426) (Polyclonal) Fluor 594
Technique	Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different
Label	ALEXA
Alternative name	ALEXA Fluor 594, antibody to-YES1 (Tyr426) (polyclonal)
Alternative technique	polyclonals
Identity	12841
Gene	YES1
Long gene name	Src family tyrosine kinase , YES proto-oncogene 1
Synonyms gene name	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
Locus	18p11, 32
Discovery year	1986-01-01
GenBank acession	M15990
Entrez gene record	7525
Pubmed identfication	2983418
RefSeq identity	NM_005433
Classification	SH2 domain containing Src family tyrosine kinases
Havana BLAST/BLAT	OTTHUMG00000131472

Anti-YES1 (Tyr426) (Polyclonal), ALEXA Fluor 594

Anti-YES1 (Tyr426) (Polyclonal), ALEXA Fluor 594 size: 100 microliters 516

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