| Long name | 1) Monoclonal Antibody, 2, ANXA1 (794CT2 |
| Also known as | 1) Monoclonal Antibody, 2, ANXA1 (794CT2 |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | ANXA1 |
| Specificity | This is a highly specific antibody against ANXA1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Monoclonal |
| Clone number | 1, 2, 794CT2 |
| Source | Purified His-tagged ANXA1 protein was used to produced this monoclonal antibody |
| Gene ID number | 301 |
| Swiss Prot | P04083 |
| Tested Applications | IHC-P, WB |
| Recommended dilutions | WB(1:1000), IHC-P(1:25) |
| Cross reactivity | Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, Has anti-inflammatory activity (PubMed:8425544), Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity), Has no effect on unstimulated T cells (PubMed:17008549), Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660), Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity), Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity), Plays a role in the formation of phagocytic cups and phagosomes, Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149), Promotes rearrangement of the actin cytoskeleton, Promotes resolution of inflammation and wound healing (PubMed:25664854), Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549), PubMed:25664854), PubMed:8557678), cell polarization and cell migration (PubMed:15187149), regulates differentiation and proliferation of activated T-cells (PubMed:17008549), Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process |
| Purification method | This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | ANXA1, Annexin A1, Annexin I, Annexin-1, Calpactin II, Calpactin-2, Chromobindin-9, LPC1, Lipocortin I, Phospholipase A2 inhibitory protein, p35, ANX1 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target | 1) Monoclonal, 2, ANXA1 (794CT2 |
| Short name | 1) Monoclonal Antibody, 2, ANXA1 (794CT2 |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name | 1) monoclonal (Antibody to), 2, annexin A1 (794CT2 |
| Alternative technique | antibodies |
| Alternative to gene target | ANX1 and LPC1, ANXA1 and IDBG-71054 and ENSG00000135046 and 301, Anxa1 and IDBG-151723 and ENSMUSG00000024659 and 16952, BT, bridging, bridging and also this GO :0033676: double-stranded DNA-dependent ATPase activity and also this GO :0036310: annealing helicase activity and also this GO :0042803: protein homodimerization activity and also this GO :0048306: calcium-dependent protein binding, bridging and molecular function this GO :0030850 and prostate gland development and biological process this GO :0031018 and endocrine pancreas development and biological process this GO :0031340 and positive regulation of vesicle fusion and biological process this GO :0031394 and positive regulation of prostaglandin biosynthetic process and biological process this GO :0031960 and response to corticosteroid and biological process this GO :0031966 and mitochondrial membrane and cellular component this GO :0032355 and response to estradiol and biological process this GO :0032508 and DNA duplex unwinding and biological process this GO :0033031 and positive regulation of neutrophil apoptotic process and biological process this GO :0033676 and double-stranded DNA-dependent ATPase activity and molecular function this GO :0036292 and DNA rewinding and biological process this GO :0036310 and annealing helicase activity and molecular function this GO :0042063 and gliogenesis and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042383 and sarcolemma and cellular component this GO :0042493 and response to drug and biological process this GO :0042629 and mast cell granule and cellular component this GO :0042803 and protein homodimerization activity and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043086 and negative regulation of catalytic activity and biological process this GO :0043234 and protein complex and cellular component this GO :0043434 and response to peptide hormone and biological process this GO :0045087 and innate immune response and biological process this GO :0046632 and alpha-beta T cell differentiation and biological process this GO :0048306 and calcium-dependent protein binding and molecular function this GO :0050482 and arachidonic acid secretion and biological process this GO :0050709 and negative regulation of protein secretion and biological process this GO :0051384 and response to glucocorticoid and biological process this GO :0060206 and estrous cycle phase and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070301 and cellular response to hydrogen peroxide and biological process this GO :0070365 and hepatocyte differentiation and biological process this GO :0070459 and prolactin secretion and biological process this GO :0070555 and response to interleukin-1 and biological process this GO :0071385 and cellular response to glucocorticoid stimulus and biological process this GO :0097350 and neutrophil clearance and biological process this GO :1900087 and positive regulation of G1/S transition of mitotic cell cycle and biological process this GO :1900138 and negative regulation of phospholipase A2 activity and biological process this GO :2000483 and negative regulation of interleukin-8 secretion and biological process, nuclei, protein binding, this GO :0000733 and DNA strand renaturation and biological process this GO :0001533 and cornified envelope and cellular component this GO :0001780 and neutrophil homeostasis and biological process this GO :0003697 and single-stranded DNA binding and molecular function this GO :0003727 and single-stranded RNA binding and molecular function this GO :0004386 and helicase activity and molecular function this GO :0004859 and phospholipase inhibitor activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005198 and structural molecule activity and molecular function this GO :0005509 and calcium ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005543 and phospholipid binding and molecular function this GO :0005544 and calcium-dependent phospholipid binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005929 and cilium and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006928 and cellular component movement and biological process this GO :0006954 and inflammatory response and biological process this GO :0007165 and signal transduction and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0009725 and response to hormone and biological process this GO :0009986 and cell surface and cellular component this GO :0010165 and response to X-ray and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0016323 and basolateral plasma membrane and cellular component this GO :0018149 and peptide cross-linking and biological process this GO :0019834 and phospholipase A2 inhibitor activity and molecular function this GO :0030073 and insulin secretion and biological process this GO :0030216 and keratinocyte differentiation and biological process this GO :0030674 and protein binding, this GO :0003697: single-stranded DNA binding, this GO :0003697: single-stranded DNA binding and also this GO :0003727: single-stranded RNA binding and also this GO :0004386: helicase activity and also this GO :0004859: phospholipase inhibitor activity and also this GO :0005102: receptor binding and also this GO :0005198: structural molecule activity and also this GO :0005509: calcium ion binding and also this GO :0005515: protein binding and also this GO :0005543: phospholipid binding and also this GO :0005544: calcium-dependent phospholipid binding and also this GO :0019834: phospholipase A2 inhibitor activity and also this GO :0030674: protein binding, this GO :0003727: single-stranded RNA binding, this GO :0004386: helicase activity, this GO :0004859: phospholipase inhibitor activity, this GO :0005102: receptor binding, this GO :0005198: structural molecule activity, this GO :0005509: calcium ion binding, this GO :0005515: protein binding, this GO :0005543: phospholipid binding, this GO :0005544: calcium-dependent phospholipid binding, this GO :0019834: phospholipase A2 inhibitor activity, this GO :0030674: protein binding, this GO :0033676: double-stranded DNA-dependent ATPase activity, this GO :0036310: annealing helicase activity, this GO :0042803: protein homodimerization activity, this GO :0048306: calcium-dependent protein binding, 70631 and IDBG-632306 and ENSBTAG00000015978 and 327662, annexin A1 |
| Identity | 533 |
| Gene | ANXA1 |
| Long gene name | annexin A1 |
| Synonyms gene | ANX1 LPC1 |
| Locus | 9q21, 13 |
| Discovery year | 2001-06-22 |
| GenBank acession | X05908 |
| Entrez gene record | 301 |
| Pubmed identfication | 2936963 |
| RefSeq identity | NM_000700 |
| Classification | Endogenous ligands Annexins |
| Havana BLAST/BLAT | OTTHUMG00000020016 |
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