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APE1 Antibody

APE1 Antibody size: 0.1ml 354

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 354
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameAPE1 Primary Polyclonal Antibody
Also known asAPE1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenAPE1
SpecificityThis is a highly specific antibody against APE1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceRecombinant human APE1 (full length) protein purified from E, coli
Gene ID number328
Swiss ProtP27695
Tested ApplicationsWB
Recommended dilutions000), WB (1:5
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB, Also involved in the DNA cleavage step of class switch recombination (CSR), Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER, Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs), May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation, On the other hand, Plays a role in the protection from granzymes-mediated cellular repair leading to cell death, Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks, The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors, and single-stranded RNA molecules, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends, single-stranded DNA regions of R-loop structures, such as the FOS/JUN AP-1 complex after exposure to IR, Multifunctional protein that plays a central role in the cellular response to oxidative stress
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names AP endonuclease 1, APE-1, APE1, APEN, APEX, APEX nuclease, APEX1, APX, Apurinic-apyrimidinic endonuclease 1, DNA-(apurinic or apyrimidinic site) lyase, HAP1, REF-1, REF1, Redox factor-1, APE
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetAPE1
Short nameAPE1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameAPE1 (Antibody to)
Alternative techniqueantibodies

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