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APEX2 Antibody, FITC Conjugated

APEX2 Antibody, FITC Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, APEX2 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenAPEX2
SpecificityThis is a highly specific antibody against APEX2
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range300-350/518
Subcellular location Mitochondrion, Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from human APEX2
Gene ID number27301
Swiss ProtQ9UBZ4
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background 3'-phosphodiesterase activities, Displays also double-stranded DNA 3'-5' exonuclease, In the nucleus functions in the PCNA-dependent BER pathway, Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, Required for proper cell cycle progression during proliferation of peripheral lymphocytes, Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes, Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents, Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends, Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Synonyms APEXL2 APE2 XTH2 ZGRF2
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetAPEX2 Conjugated
Short name FITC Conjugated, APEX2 Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, APEX2 (Antibody to)
Alternative techniqueantibodies
Identity 17889
Gene APEX2
Long gene name apurinic/apyrimidinic endodeoxyribonuclease 2
Synonyms gene name APEX nuclease (apurinic/apyrimidinic endonuclease) 2
Synonyms name GRF-type containing 2 , zinc finger
Locus Xp11, 21
Discovery year 2002-07-22
GenBank acession AB021260
Entrez gene record 27301
Pubmed identfication 11376153
Classification Zinc fingers GRF-type
Havana BLAST/BLAT OTTHUMG00000021642
Locus Specific Databases Mental Retardation database

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